T-cell receptors and human leukocyte antigens in primary sclerosing cholangitis

A brief introduction to the adaptive immune system The T-cell receptor Human leukocyte antigens and linkage disequilibrium T HE HUMAN LIVER PSC etiology and pathogenesis I: Genes and environmental factors PSC etiology and pathogenesis II: Pathogenic models S TUDY POPULATIONS AND STARTING MATERIAL Considerations concerning high-throughput TCR sequencing strategy Nomenclature and analyses of TCRβ sequencing data T HE PSC T- CELL REPERTOIRE