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Genetic biomarkers as prognostic and predictive factors in metastatic malignant melanoma

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Appendix

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Table A1: Melanoma TNM Classification

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Table A2: Clinical and pathologic staging system

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Table A3: Clarks level of invasion

Level I: Melanomas confined to the outermost layer of the skin, the epidermis. Also called "melanoma in-situ."

Level II: Penetration by the melanocytes into the second layer of the skin, the outermost part of the dermis, the papillary dermis

Level III: The melanocytes has invaded the interface between papillary and reticular dermis and compresses the reticular dermis

Level IV: Melanocytes invade deeper through the dermis, into the reticular dermis, but completely within the skin.

Level V: Penetration of melanocytes into the fat of the skin beneath the dermis, penetration into the third layer of the skin, the subcutaneous tissue.

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