• No results found

3.  Fylkesvis presentasjon og analyse av data

3.7  Hordaland

 O grupo PYCN apresentou baixo fluxo salivar

 Ambos os grupos apresentaram média de pH de repouso dentro dos parâmetros de normalidade

 O grupo PYCN apresentou menores valores de pH e fluxo salivar em relação aos pacientes sadios não-sindrômicos;

 O grupo PYCN apresentou valores aumentados de concentração total de proteínas em relação ao grupo de pacientes sadios não-sindrômicos;

 O grupo PYCN apresentou um padrão diferenciado no que se refere a quantidade de spots, além de variação e distribuição da massa molecular dos mesmos em relação ao grupo de pacientes sadios não-sindrômicos;

REFERÊNCIAS

AGUIRRE, A.; TESTA-WEINTRAUB, L. A.; BANDERAS, J. A.; HARASZTHY, G. G.; REDDY, M. S.; LEVINE, M. J. Sialochemistry: a diagnostic tool? Crit Rev Oral Biol Med, Alexandria, v. 4, n. 3-4, p. 343-350,1993.

ANDRADE, P.P.; IGLESIAS, D.P.P.; SOUZA, E.L; FREITAS, R.A.; GALVÃO, H.C.; Saliva: Métodos Atuais para Coleta e Obtenção da Amostra Fac. Odontol. Porto Alegre, v. 48, n. 1/3, p. 95-98, 2007

APS, J.K.M.; MARTENS, L.C. Review: the physiology of saliva and transfer of drugs into saliva. Forensic Sci Int. v. 150, p. 119–31, 2005.

ARYANPUR, J., HURKO, O., FRANCOMANO, C., WANG, H., CARSON, B.

Craniocervical decompression forcervicomedullary compression in pediatric patients with achondroplasia. J. Neurosurg. v. 73, p. 375-82, 1990.

AZEN, E. A. Genetics of salivary protein polymorphisms. Crit Rev Oral Biol Med, Alexandria, v. 4, n. 3-4, p. 479-485, 1993.

BANDERAS-TARABAY, J.A . Flujo y concentracion de protefnas en saliva total humana . Salud Publica Mex , v. 39, n. 5, p. 433-41, 1997.

BALCI, S.; ERCAL, M.D.; SAY, B; ATASU, M.; Robinow syndrome: with specialemphasis on dermatoglyphics and hand malformations (split hand). Clin Dysmorphol;v. 2, p.199-207, 1993.

BATHI, R .J.; MASUR, V.N. Pycnodysostosis: a report of two cases with a brief review of the literature. Int J Oral Maxillofac Surg. v. 29, p.439-42, 2000.

BERTOLA, D.; AMARAL, C.; KIM, C.; ALBANO, L.; AGUENA, M., PASSOS-BUENO, M.R. Craniosynostosis in pycnodysostosis: broadening the spectrum of the cranial flat bone abnormalities. Am J Med Genet A. v. 152ª, n. 10, p. 2599-603, 2010.

BOLSCHER, J.G.; NAZMI, K.; RAN, L.J.; VAN ENGELENBURG, F.A.;

SCHUITEMAKER, H.; VEERMAN, E.C.; NIEUW AMERONGEN, A.V.; Inhibition of HIV-1 IIIB and clinical isolates by human parotid, submandibular, sublingual and palatine saliva.; Eur J Oral Sci. v. 110, n.2, p. 49-56, 2002.

BRETAS, L. P.; ROCHA, M. E.; VIEIRA, M. S.; RODRIGUES, A.C.P. Fluxo salivar e capacidade tamponante da saliva como indicadores de susceptibilidade à doença cárie / Flow rate and buffering capacity of the saliva as indicators of the susceptibility to caries disease. Pesqui. bras. odontopediatria clín. Integr. v.8, n.3, 2008.

BRENNAN, A.M, PAULI, R.M. Hajdu-Cheney syndrome: Evolution of phenotype and clinical problems.Am J Med Genet.;100:292–310; 2001.

CARRANZA, M.; FERRARIS, M.E.; GALIZZI, M.; Structural and morphometrical studyin glandular parenchyma from alcoholic sialosis. J Oral Pathol & Med. v.34, n.6, p.374–9, 2005

CHAPPLE, I.L.; GLENWRIGHT, H.D.; MATTHEWS, J.B.; THORPE, G.H.; LUMLEY, P.J.; Site-specific alkaline phosphatase levels in gingival crevicular fluid in health and gingivitis: cross-sectional studies. J Clin Periodontol. v. 21, n. 6, p. 409-14, 1994.

CHAPPIN, S; ; ANTONELLI, G.; DE PALO, E.F.; Saliva specimen: a new laboratory tool for diagnostic and basic investigation; Clin Chim Acta. v.383, n. 1-2, p. 30-40, 2007.

COSTIGAN, D.C.; GUYDA, H.J.; POSNER, B.I.; Free insulin-like growth factor I (IGF-I) and IGF-II in human saliva.; J Clin Endocrinol Metab. v. 66, n.5, p.1014-8, 1988.

CRESPI, P. Displasia cleidocraniana. In: Regesi J A., Sciubb J. J. Patologia bucal. Rio de Janeiro: Guanabara Koogan, 1991.

CLANCY, K.A.; PEARSON, S.; BOWEN, W.H.; BUENE R.A.;. Characterization of recombinant, ureolytic Streptococus mutans demonstrates na inverse relationship between dental plaque ureolytic capacity and cariogenicity. Infect Immun. v.68, n.5, p.2621-9, 2000

CRUZ,O.L.M.; PESSOTO, J.; PEZATO, R..; ALVARENGA, E.L. Osteodistrofias do osso temporal: Revisão dos conceitos atuais manifestações clínicas e opções terapêuticas.Bras Otorrinolaringol.v. 68, p. 119- 26, 2002.

DAWES, C. The effects of flow rate and duration of stimulation on the concentrations of protein and the main electrolytes in human parotid saliva, Archives of Oral Biology. v.5 p. 277–294;1969.

DAWES, C. Considerations in the development of diagnostic tests on saliva.Ann N Y Acad Sci. v. 20, n. 694, p. 265-269, 1993.

DAWES, C. How much saliva is enough for avoidance of xerostomia? Caries Res. v. 38, n. 3, p.236-40, 2004.

DIBDIN, G.H.; DAWES, C.A. A mathematical model of influence on the pH of fasted dental plaque and on the changes occurring during a cariogenic challenge. Caries Res. v. 32, n.1, p. 70-4, 1998

DICHETCHEKE NIAN, V.; MARCONDES, E.; CLAUDETTE, H.G. Acondroplasia: Revisão com ênfase nos aspectos radiológicos. J Pediatric.v. 9, p. 103-13, 1987.

DODDS MW, JOHNSON DA, YEH CK. Health benefits of saliva: a review. J Dent. v.33, n.3, p. 223-33, 2005

DOUGLAS, C. R. Patofisiologia oral: fisiologia normal e patológica aplicada a odontologia e fonoaudiologia. São Paulo: Pancast, 1998. p.17-38.v.2; 1998.

EDELSON, J.G.; OBAD, S.; GEIGER, R.; ARTUL, H.J. Pycnodysostosis. Orthopedic aspects with a description of 14 new cases.Clin Orthop.v. 280, p. 263-76, 1992.

EDGAR, W.M.; O’MULLANE, D.M. Saliva and oral health. 2.ed. London: British

DentalAssociation,. p. 140, 1996.

EDGAR, W.M.; Saliva and dental health.Clinical implications of saliva: reportof a consensus meeting. Br Dent J. v.169, p. 96-8, 1990.

ELMORE, S.M. Pycnodysostosis: a review. J Bone Joint Surg. v. 49A, p.153-63, 1967.

FALCÃO, D.P. Avaliação da Viscosidade Salivar e sua Relação com a Halitose. 2005.133f. Dissertação (Mestrado em Ciências da Saúde – Estomatologia) - Faculdade de Odontologia, Universidade de Brasília, Brasília.

FANO V.; LEJARRAGA H. Hallazgos frecuentes em la atención clínica de 96 ninõs con acondroplasia. Arch Argent. Pediatr, v.98, n.6, p. 368, 2000.

FEJERSKOV, O.; KIDD, E.A.M. Cárie Dentária: a doença e seu tratamento clínico. São Paulo: Santos; 2005. p. 72-96.

FERNÁNDEZ MARIÑO, E.A.; PALLARDO SÁNCHEZ L.F.; GRACIA BOUTELIER R.; SÁENZ DEL CASTILLO I. Pycnodysostosis. Radiological and endocrinological study. Rev Clin Esp. v. 28, n. 4, p. 261-5, 1981.

FONTELES, C.S.R; CHAVES, JR, C.M.; DA SILVEIRA, A.; SOARES, E, COUTO, J.L.P. Cephalometric characteristics and dentofacial abnormalities of Pycnodysostosis: report of four cases from Brazil. Oral Surg Oarl Med Oral Pathol Oral Radiol Endod. v. 104, n. 83- 90, 2007.

FORDE, M.D.; KOKA, S.; ECKERT, S.E,; CARR, A.B.; WONG, D.T. Systemic assessments utilizing saliva: part 1 general considerations and current assessments. Int J Prosthodont.v. 19, n.1, 43-52, 2006.

FORLAN, M. Cleidocranial dysostosis. Am J Med. v.33, n.2, p. 792- 799, 1962.

FRANCOMANO, C.A.; ORTIZ, R.I.; HEFFERSON, T.W.; BELLUS, G.A.; TURNER, E. Localization of the achondroplasia gene to the distal 2, 5 Mb of human chromosome 4p. Hum Mol Genet. v. 3, p. 787-92, 1994.

GANDHY, M, DAMLE, S.G.; Relation of salivary inorganic phosphorus and alkaline phosphatase to the dental caries status in children.; J Indian Soc Pedod Prev Dent. Dec;21(4):135-8; 2003.

GARCIA, J.; MONTEIRO, P.; SAAVEDRA, M. J.; SILVA, J.; MALCATA, A.; Do e n ç a de C a m u r at i - E n g e l m a n n. Órgão oficial da sociedade portuguesa de reumatologia - Acta Reum Port. v.32, n. 395-396, 2007.

GELB, B.D.; SHI, G.P.; CHAPMAN H.A.; DESNICK R.J. Pycnodysostosis a lysosomal disease caused by cathepsin K deficiency. Science.v. 273, p. 1236-8, 1996.

GHAFOURI, B.; TAGESSON, C.; LINDAH,L.M.; Mapping of proteins in human saliva using two-dimensional gel electrophoresis and peptide mass fingerprinting. Proteomics. v. 3, p.1003-15, 2003.

GHEZZI, E.M.; LANGE, L.A.; SHIP, J.A.; Determination of variation of stimulated salivary flow rates.; J Dent Res. v. 79, n.11, p.1874-8, 2000.

GIANNOBILE, W.V.; BEIKLER, T.; KINNEY, J.S.; RAMSEIER, C.A.; MORELLI, T.; WONG, D.T.; Saliva as a diagnostic tool for periodontal disease: current state and future directions.; Periodontol, v. 50, p. 52-64, 2000.

GONÇALVES, L.R.; SOARES, M.R.; NOGUEIRA, F.C.;, GARCIA, C.; CAMISASCA, D.R.; DOMONT, G.; FEITOSA, A.C.; PEREIRA, D.A.; ZINGALI, R.B.;, ALVES, G.;; Comparative proteomic analysis of whole saliva from chronic periodontitis patients.; J Proteomics. v. 7, n. 7, p. 1334-41, 2010.

GRIFFITHS, A.J.F.; GELBART, W.M.; MILLER, J.H.; LEWONTIN, R.C. A herança de genes, In: Waters JC, Cole RW, Rieder CL, editors. Genética Moderna, Rio de Janeiro: Guanabara Koogan, 2001, p. 104-107.

GUVEN, M.A.; BATUKAN, C.; CEYLANER, S..;UZEL M.; OZBEK, A.; Demirpolat G. Prenatal and postnatal findings in a case with autosomal recessive type of Robinow syndrome. Fetal Diagn Ther.v. 21, p. 386–9, 2006.

HAMERSMA, H. Osteopetrosis (Marble Bone Disease) of the temporalbone. Laryngoscope. v.80, p. 1518-39, 1970.

HECHT, J.C.C.; FRANCOMANO, C.A..; HORTON, W.A. .Mortality in achondroplasia. Am F Hum Genet1987; 41:454-64, 1987.

HELMERHORST, E.J.; OPPENHEIM, F.G. Saliva: a dynamic proteome. J Dent Res. v.86, n.8, p. 680-93, 2007

HERNÁNDEZ-ALFARO, F., ARENAZ BÚA, J., SERRA SERRAT, M., MAREQUE BUENO, J. Orthognathic surgery in pycnodysostosis:a case report. Int J Oral Maxillofac Surg. v. 40, n. 1; p. 110-3, 2011.

HOSALKAR, H.S.; SHAW, G.J.; Robinow syndrome.J Postgrad Med. v.48, p. 50–1, 2002.

HUMPHREY, S.P.; WILLIAMSON, R.T. A review of saliva: Normal composition, flow, and function. J Prosthet Dent. v. 85, n. 2, p. 162-169, 2001.

HUNT, N.P.; CUNNINGHAM, S.J.; ADNAN, N.; HARRIS,M. The dental, craniofacial, and biochemical features of pyknodysostosis: a report of three new cases. J Oral Maxillofac Surg.v. 56, p. 497-504,1998.

JANSSENS, K.; VANHOENACKER, F.; BONDUELLE, M;. Camurati- Engelmann disease: review of the clinical, radiological, and the molecular data of 24 families and implications for diagnosis and treatment. J Med Genet. v. 43, p.1-11, 2006.

JENKINS, G.N. The Physiology of the Mouth. The Alden Press, Great Britain, 3th.ed., p. 289, 1970.

JENSEN, J.L.; BRODIN, P.; BERG, T.; AARS, H.; Parotid secretion of fluid, amylase and kallikrein during reflex stimulation under normal conditions and after acute administration of autonomic blocking agents in man.; Acta Physiol Scand. v. 143, n. 3, p.321-9, 1991.

KALLIALLA, E.; TASKINEN, P.J. Cleidocranial dysostosis.Oral Surg 1962; 15(8): 808- 822.

KATO, H.; MATSUOKA, K.; KATO, N.; OHKUBO, T. Mandibular osteomyelitis and fracture successfully treated with vascularize diliac bone graftina patient with

pycnodysostosis. Br J Plast Surg. v. 58, n. 263–266, 2005.

KAUFMAN, E.; LAMSTER, I. B. Analysis of saliva for periodontal diagnosis – a review. J Clin Periodontol,Copenhagen, v. 27, n. 7, p. 453-65, 2000.

KELLY, E.; NAKAMOTO, R.Y. Cleidocranial dysostosis – a prosthodontic problem.J Prosthet Dent.v. 31, n. 5, p. 518-526, 1974.

KHAWALI ,C.; REZENDE, C.A.C.; CASTRO, M.L. Retardo de desenvolvimento associado a osteopetrose. Arq Bras Endocrinol Metab. v.42: p. 483-8, 1998.

KIRSON, L.E.; SCHEIBER, R. E.; TOMARO, A. J. Multiple impacted teeth in cleidocranial dysostosis. Oral Surg. v. 54, n. 5, p. 604-605, 1982.

KOPITS S.E. Orthopedic complications of dwarfism.Clin Orthop Rel Res, 114:153-79, 1976.

KOSS, M.A.; CASTRO, C.E.; SALÚM, K.M.; LÓPEZ, M.E.;Changes in saliva protein composition in patients with periodontal disease. Acta Odontol LatinoAm. v.22, n. 2, p. 105- 12, 2009.

LANDA, S.; ESTEBAN, S.; MONTES, E.; SANTAMARIA, J.; VITORIA, A.; SANTOLAYA, J.M. Maxillofacial alterations in a family with pycnodysostosis. Med Oral.v.5, p.169-76, 2000.

LAWRENCE, H.P. Salivary markers of systemic disease: non-invasive diagnosis of disease and monitoring of general health. J Can Dent Assoc. v. 68, n. 3, p. 170-4, 2002.

LAZNER, F.; GOWEN, M.; PAVASOVIC, D.; KOLA, I. Osteopetrosis and osteoporosis: two sides of the same coin. Humam Molecular Genetics. v. 8, n. 10, p1839–1846, 1999.

LEITE, G.J.; MAMEDE, R.C.M.; LEITE, M.G.J. Medida do Fluxo Salivar: Refinamentosao Método do Cuspe e Usodo Papel de Filtro. Rev. Brasil. Otorrinolaringol. v.68,n.6, p.826- 832, 2002.

LENANDER-LUMIKARI, M.; LOIMARANTA, V. Saliva and dental caries; Adv Dent Res. v. 14, p. 40-7, 2000.

LEWIS, J.G.; Steroid analysis in saliva: an overview; Clin Biochem Rev. v.27, n.3, p.139-46, 2006.

LIMA, R.L.O.; SILVA, M.C.P; CERVAN, M.P.; COSTA, R.F. Acondroplasia: revisão sobre a doença. Arq. Sanny Pesq. Saúde, v. 1, n. 1, p. 83-89, 2008.

LLENA-PUY, C.; The rôle of saliva in maintaining oral health and as an aid to diagnosis. Med Oral Patol Oral Cir Bucal; 11:E449-55; 2006.

MAGALHÃES, T.J.S..; ROTBAND, I.; CAVALCANTE, A.L.; GIESTA, C. Picnodisostose. Brás Ortop. v.33, n. 09, p.749-52, 1998.

MANDEL, I.D. Salivary diagnosis: promises, promises. Ann N Y Acad Sci. v. 20, n. 694, p. 1-10, 1993.

MAROTEAUX, P.; LAMY, M. The malady of Toulouse-Lautrec.JAMA, v. 191, p.11-3, 1965.

MAZZEU, J.F.; PARDONO, E.; VIANNA-MORGANTE, A.M.;Clinical characterization of autosomal dominant and recessive variants of Robinow syndrome.Am J Med Genet

Am.v.143, p.320–5, 2007.

MILROY, C.M.; MICHAELIS, L. Temporal Bone Pathology of Adult – Type Osteopetrosis. Arch Otolaryngol Head Neck Surgv. v. 116, p. 79-84, 1990.

MOURA, S.A.B.; MEDEIROS, A.M.C.; COSTA, F.R.H.; MORAES, P.H.; OLIVEIRA FILHO,S.A.. - Valor Diagnóstico da Saliva em Doenças Orais e Sistêmicas. Pesq Bras Odontoped Clin Integr, v. 7, n. 2, p. 187-194, 2007.

MUJAWAR, Q.; NAGANOOR, R.; PATIL, H.; THOBBI, A.N.; UKKALI ,S.; MALAGI, N. Pycnodysostosis with un usual findings: a casereport. Cases J. v. 23, p.6544, 2009.

MUTO, T.; YAMAZAKI, A.; TAKEDA, S.; TSUJI, Y.; SHIBATA, T.

Pharyngealnarrowingasacommon featurein pycnodysostosis- a cephalometric study. Int J Oral Maxillofac Surg. v. 34, p. 680-85, 2005.

MYAMOTO, R.T.; HOUSE,W.F.; BRACKMANN,D.E. Neurotologic manifestations of the osteopetrosis. Arch Otolaryngol.v.106, p. 210-4,1980.

MYERS, E.N.; STOOL, S. The temporal bone in osteopetrosis.Arch Otolaryngol. v. 89, p. 44, 1969.

NAGLER, R.M.; HERSHKOVICH, O.; LISCHINSKY S; DIAMOND, E.; REZNICK, A.Z;Saliva analysis in the clinical setting: revisiting an underused diagnostic tool. J Investig Med. v. 50, n. 3, p. 214–25, 2002.

NAUNTOFTE, B.; BARDOW, A.; HOFER, E.; NYVAD, B.; TEN CATE, J.M.; KIRKEBY, S.; MOE, D.; Effect of saliva composition on experimental root caries. Caries Res. v.39, n.1, p. 71-7, 2005.

N'DOBO-EPOY, P.; GNAGNE-AGNERO KOFFI, N.D.; SESS, E.D.; GUINAN, J.C.; BAKAYOKO, L.Y .R. Comparison of the clinical detection and the biological detection of dental caries. Odontostomatol Trop., v.24, n.96, p. 5-8, 2001

NIELSEN, E. Pycnodysotosis: six cases with simptoms and autopsy. Acta Paed. Scand. v. 63,p. 437, 1974.

NISHI, Y.; ATLEY, L.; EYRE, D.E.; EDELSON, J.G.; SUPERTI-FURGA, A.; YASUDA, T.; DESNICK, R.J.; GELB, B.D. Determination of bone markers in pycnodysostosis: effects of cathepsin K deficiency on bone matrix degradation. J Bone Miner Res. v. 14, n. 11, p. 1902-8, 1999.

NØRHOLT, S.E.; BJERREGAARD, J.; MOSEKILDE, L. Maxillary distraction osteogenesis in a patient with pycnodysostosis: a case report.J Oral Maxillofac Surg. v. 62, p. 1037–1040, 2004.

O’ CONNEL, A.C., BRENNAN, M.T., FRANCOMANO, C.A. Pycnodysostosis: orofacial

ORNETTI ,P.; PRATI, C.; FERY-BLANCO,C.; STREIT, G.; TOUSSIROT,E.; WENDLING, D. Pediclestress fracture: an unusual complication of pycnodysostosis. Clin.Rheumatol. v. 27, n. 385-87; 2008.

OTTO, P.G.; OTTO, P.A.; PESSOA, O.F. Acondroplasia, In Otto PG, Otto PA, Pessoa OF. Genética humana e clínica. Roca, p.153-158, São Paulo, 1998.

PANDEY, A.; MANN, M. Proteomics to study genes and genomes. Nature. v. 15, n.6788, p. 37-46, 2000

PATTON, M.A.; AFZAL, A.R. Robinow syndrome.J Med Genet. v. 39, n. 305–310, 2002.

PAULI, R.M.; HORTON, V.K.; GLINSKI, L.P.; REISER, C.A. Prospective assessment of risks forcervicomedullary junction compression in infants with achondroplasia. Am J Hum Genet.v.56, p. 732-44, 1995.

PEREIRA, D.A; BERINI AYTE´S, L., GAY ESCODA, C. Pycnodysostosis: a report of 3 clinical cases. Med Oral Pathol Oral Cir Bucal. v.13, p. 633-35, 2008.

PERINPANAYAGAM HE, VAN WUYCKHUYSE BC, JI ZS, TABAK LA.Characterization of low-molecular-weight peptides in human parotid saliva.. J Dent Res. 1995 Jan;74(1):345- 50.

PLOTKIN, H. Syndromes with congenital brittle bones.BMC Pediatr.v. 4, p. 16, 2004.

PUY, L.C. The role of saliva in maintaining oral health and as an aid to diagnosis. Med Oral Patol Oral Cir Bucal. v. 11, p. E449-55, 2006.

QUEZADO, R.; MONTENEGRO JR, R.M.; ARARIPE, F.F.A.; CORRÊA, R.V.

Picnodisostose: relato de dois casos. Arq Brás Endocrinol Metab. v.47, n. 1, p. p.62-68, 2003.

RAUCH, F.; GLORIEUX, F.H. Osteogenesis imperfecta.Lancet, v. 363, p.1377-85, 2004.

RIMOIN DL. Cervicomedullary junction compression in infants with achondroplasia:when to perform neurosurgical decompression. Am J Hum Genet.v.56, p. 824-6, 1995.

ROBINOW, M. The Robinow (fetal face) syndrome: a continuing puzzle.Clin Dysmorphol. v. 2, p.189-98, 1993.

ROUGHLEY, P.J., RAUCH, F., GLORIEUX ,F.H. Osteogenesis imperfecta - clinical and molecular diversity. Eur Cell Mater.v. 5, p. 41-7, 2003.

RUDENKO,M.M.; Metabolic desordens and their correction I schoolchildren with different forms of caries. Stomatologia, New York, v.70, n.1, p.55-59, 1991.

SAITO, M. I. ; GONZALEZ, C. H. . Caso em foco: Picnodisostoses. Pediatria, v. 10, p. 34- 38, 1988.

SCHILLING AF, MÜLHAUSEN C, LEHMANN W, SANTER R, SCHINKE T, RUEGER JM, AMLING M. High bone mineral density in pycnodysostotic patients with a novel mutation in the propeptide of cathepsin K. Osteoporos Int. v. 18, n. 5, p. 659-69, 2007.

SCHIPPER, R.G. Saliva as research material: Biochemical, psycochemical and pratical aspects. Archieves of oral Biology. v. 52, n. 12, p.1114-35, 2007

SCOTT C.I.J.; HUNTER A.G.W.; BANKIER A.; ROGERS J.G.; SILENCE D. Medical complications of achondroplasia: a multicentre patient review. J Med Genet. v. 35, p. 705- 712, 1998.

SHATZMAN, A.R.; HENKIN, R.I. Gustin concentration changes relative to salivary zinc and taste in humans. Proc Natl Acad Sci . v. 78, n. 6, p. 3867-71, 1981.

SHIP, J.A.; Diagnosing, managing, and preventing salivary gland disorders.; Oral Dis.v.8, n.2, p.77-89, 2002.

SILVA, J.J.; SILVA, M.C.A. Disostose Cleido Cranial. RGO. v. 42, n. 5, 281-282, 1994.

SIQUEIRA JUNIOR, W.L.; Estudo de alguns parâmetros salivares em indivíduos com Síndrome de Down / Walter Luiz Siqueira Junior; orientador José Nicolau. -- São Paulo, 2004. 140p.

SOLIMAN, A.T.; RAJAB, A.; AL-SALMI, I.; DARWISH, A.; ASFOUR, M. Defective growth hormone secretion in children with pycnodysostosis and improved linear growth after growth hormone treatment. Arch Dis Child.v.75, p.242-4, 1996.

SOLIMAN, A.T.; RAMADAN, M.A.; SHERIF, A.; ZIZ BEDAIR, E.S.; RIZK, M.M. Pycnodysostosis: clinical,radiologic,andendocrine evaluation and linear growth after growth hormonetherapy. Metabolism. v. 50, p. 905–911, 2001.

SOLIMAN, A.T.; RAJAB, A.; ALSALMI, I.; BEDAIR, S.M.A;. Recessive Robinow syndrome: With emphasis on endocrine functions. Metabolism. v. 47, p.1337–43,1998.

SOUZA, S.L.; TABA, M. JR. Cross-sectional evaluation of clinical parameters to select high prevalence populations for periodontal disease: the site comparative severity methodology. Braz Dent J. v.15, n.1, p. 46–53, 2004

SREEBNY, L. M. Saliva in health and disease: an appraisal update. Int. Dent. J. v. 50, n. 3, p. 140-161, 2000.

STRECKFUS, C.F.; BIGLER, L.R. Saliva as a diagnostic fluid. Oral Disease. v. 8, n. 2, p.69-76, 2002.

STREUBEL, S.O.; LUSTIG, L.R. Cochlear implantation in patients with osteogenesis imperfecta.Otolaryngol Head Neck Surg. v. 132, n. 5, p. 735-40, 2005.

SUGA ,F., LINDSAY, J.R. Temporal bone histopathology of osteopetrosis. Ann Otol Rhinol Laryngolv. 85, p. 15-24, 1976.

SURESH, S.; SUJATHA MOHAN, S.; MISHRA, G.; HANUMANTHU, G.R.; SURESH, M, REDDY, R. PANDEY, A.; Proteomic resources: integrating biomedical information in humans.; Gene, v. 30, p. 364:13-8, 2005

TABA, M. JR; KINNEY, J.; KIM ,A.S.; GIANNOBILE, W.V. Diagnostic biomarkers for oral and periodontal diseases.; Dent Clin North Am. v. 49, n. 3, p.551-71, 2005

TANG, X.; PAN, Y.; WANG, Z. Sodium dodecyle sulphate polyacrylamide gel

electrophoresis in whole salivary proteins from patients with adult periodontitis. Hua Xi Kou Qiag Yi Xue Za Zhi, Cheng-Tu, v. 21, n. 2, p. 98-100, 2003.

TANNER, J.M.; WHITEHOUSE,R.H..Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty.Arch Dis Child.v. 51, p.170-9, 1976.

TAO, R.; JUREVIC, R.J.; COULTON, K.K.; TSUTSUI, M.T.; ROBERTS, M.C.;

KIMBALL, J.R. et al. Salivary antimicrobial peptide expression and dental caries experience in children. Antimicrob Agents Chemother. v. 49, n. 9, p. 3883-8, 2005.

TASKER, R.C.; DUNDAS, I.; LAVERTY,A.; FLECTHER, M, LANE, R, STOCKS,J. Distinct patterns of respiratorydifficulty in young children with achondroplasia: a clinical, sleep and lung function study. Arch Dis Child. v. 79, p.99-108, 1998.

TEISSIER, N.; JACQUEMONT, M.L.; BLANCAL, J.P.; ELMALEH-BERGE, S. M.; VAN DEN ABBEELE, T.; BENNACEUR, S. Severe snor ing in a child with pycnodysostosis treated with a bilateral rib graft. Cleft Palate Craniofac J. v. 46, n. 93–96, 2009.

VAN BOKHOVEN, H.; CELLI, J.; KAYSERILI, H.; VAN BEUSEKOM, E.; BALCI, S.; BRUSSEL, W.; SKOVBY, F.; KERR, B.; PERCIN, E.F.; AKARSU, N.; BRUNNER, H.G.;Mutation of thegene encoding the ROR2 tyrosine kinase causes autosomal recessiveRobinow syndrome. Nat Genet. v. 25, p. 423-6, 2000.

vAN HOUTE, J. Microbiological predictors of caries risk. Adv Dent Res. v. 7, n. 2, p. 87-96, 1993

VAN NIEUW AMERONGEN, A.V.; BOLSCHER, J.G.;, VEERMAN, E.C.I.; Salivary proteins: protective and diagnostic value in cariology?; Caries Res. v. 38, n.3, p.247-53, 2004.

VAN NIEUW AMERONGEN, A.V.; VEERMAN, E.C.I.;Saliva — the defender of theoral cavity. Oral Dis, v. 8, n. 12–22, 2002.

VANHOENACKER , F.M.; DE BEUCKELEER, L.H.; VAN HUL, W.; BALEMANS, W.; TAN, G.J.; Hill, S.C. et al. Sclerosing bone dysplasias: genetic and radioclinical features. Eur Radiol.v. 10, p. 1423-33, 2003.

WARKANY, J. Achondroplasia in congenital malformations. In: YEAR Book. Chicago: Medical Publishers, 1971. p. 768.

WEINSTEIN, S.L.; BUCKWALTER,A.J. Tecidos músculo-esqueléticos e sistema músculo- esquelético. In: Buckwalter JA, Weinstein SL, editores. Ortopedia de Turek: princípios e sua aplicação.São Paulo: Manole, 2000.p.13-68.

WHYTE, M.P. Osteogenesis imperfecta. In: Favus MJ, editor. Primer on the metabolic bone diseases and disorders of mineral metabolism. New York: Raven Press. v. 2, p. 386-9, 1999.

Wong, D.T. Salivary diagnostics for oral cancer. J Calif Dent Assoc. v.34, n.4, p. 303-8, 2006.

WU, Y.; SHU, R.; LUO, L.J.; GE, L.H.; XIE, Y.F.; Initial comparison of proteomic profiles of whole unstimulated saliva obtained from generalized aggressive periodontitis patients and healthy control subjects. ; J Periodontal Res. v. 44, n.5, p.636-44, 2009.

YAO, Y.; BERG, E.A.; COSTELLO, C.E.; TROXLER, R.F.; OPPENHEIM, F.G. Identification of protein components in human acquired enamel pellicle and whole saliva using novel proteomics approaches. J Biol Chem. v. 14, n. 7, p. 5300-8, 2002.

ZENKE, M.S.; HATORI, M.; TAGO, S.; HOSAKA, M.; KOKUBUN, S. Pycnodysostosis associated with spondylolysis.Arch Orthop Trauma Surg. v. 122, n. 4, p. 248-50, 2002.

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FICHA DE ANAMNESE