2. Attraktivitetsbarometeret
2.1. Befolkning
Há uma menor densidade de mastócitos em carcinomas epidermóides de boca quando comparado a hiperplasias fibroepiteliais e displasias epiteliais.
Há aumento da angiogênese quando a lesão torna-se maligna. Entretanto, não há alteração da vascularização quando comparadas hiperplasias fibroepiteliais e displasias epiteliais.
Não foi possível encontrar correlação entre mastócitos e angiogênese em lesões potencialmente malignas e câncer de boca, indicando que nos carcinomas de células escamosas orais não há participação dessa célula no processo de angiogênese.
REFERÊNCIAS
ABBAS, N. F. et al. Immunohistochemical study of p53 and angiogenesis in benign and preneoplastic oral lesions and oral squamous cell carcinoma. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, v. 103, n. 3, p. 385- 90, Mar 2007. ISSN 1528-395X (Electronic)
ACIKALIN, M. F. et al. Tumour angiogenesis and mast cell density in the prognostic assessment of colorectal carcinomas. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, v. 37, n. 3, p. 162-9, Mar 2005. ISSN 1590-8658 (Print) AL-HARRIS, E. S. et al. Over expression of vascular endothelial growth factor in correlation to Ki-67, grade, and stage of breast cancer. Saudi Med J, v. 29, n. 8, p. 1099-104, Aug 2008. Disponível em: <
ALKHABULI, J. O. Significance of neo-angiogenesis and immuno-surveillance cells in squamous cell carcinoma of the tongue. The Libyan journal of medicine, v. 2, n. 1, p. 30-9, 2007. ISSN 1993-2820 (Print)
ARNES, J. B. et al. Vascular proliferation is a prognostic factor in breast cancer. Breast cancer research and treatment, Sep 27 2011. ISSN 1573-7217 (Electronic) ARTESE, L. et al. Microvessel density (MVD) and vascular endothelial growth factor expression (VEGF) in human oral squamous cell carcinoma. Anticancer Res, v. 21, n. 1B, p. 689-95, Jan-Feb 2001.
ASAHARA, T. et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circulation research, v. 85, n. 3, p. 221-8, Aug 6 1999. ISSN 0009-7330 (Print) BARBARESCHI, M. et al. Microvessel density quantification in breast carcinomas. Assessment by light microscopy vs. a computer-aided image analysis system. Appl Immunohistochem, v. 3, p. 75-84, 1995.
BERGERS, G.; BENJAMIN, L. E. Tumorigenesis and the angiogenic switch. Nature reviews. Cancer, v. 3, n. 6, p. 401-10, Jun 2003. ISSN 1474-175X (Print)
BRAHIMI-HORN, C.; BERRA, E.; POUYSSEGUR, J. Hypoxia: the tumor's gateway to progression along the angiogenic pathway. Trends Cell Biol, v. 11, n. 11, p. S32- 6, Nov 2001.
BRASIL, I. N. D. C.-. Estimativa 2012 : incidência de câncer no Brasil. Rio de Janeiro: Inca: 188 p. 2011.
CAVALCANTE, A. S.; ANBINDER, A. L.; CARVALHO, Y. R. Actinic cheilitis: clinical and histological features. J Oral Maxillofac Surg, v. 66, n. 3, p. 498-503, Mar 2008.
CEDENO, F.; TONINO, P. Angiogénesis en lesiones premalignas y malignas de la mucosa bucal. Acta odontol. venez, v. 43, n. 2, p. 108-112, 2005. ISSN ISSN 0001-6365.
CHAN, J. K. et al. Mast cell density, angiogenesis, blood clotting, and prognosis in women with advanced ovarian cancer. Gynecologic oncology, v. 99, n. 1, p. 20-5, Oct 2005. ISSN 0090-8258 (Print)
CHRISTIAN, D. C. Computer-assisted analysis of oral brush biopsies at an oral cancer screening program. J Am Dent Assoc, v. 133, n. 3, p. 357-62, Mar 2002. DABIRI, S. et al. The presence of stromal mast cells identifies a subset of invasive breast cancers with a favorable prognosis. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, v. 17, n. 6, p. 690-5, Jun 2004. ISSN 0893-3952 (Print)
DE LA TORRE, N. G. et al. Angiogenesis and lymphangiogenesis in thyroid
proliferative lesions: relationship to type and tumour behaviour. Endocrine-related cancer, v. 13, n. 3, p. 931-44, Sep 2006. ISSN 1351-0088 (Print)
DORNELAS, C. A. Efeito da própolis verde na carcinogênese e angiogênese de tumores da bexiga induzidos pelo bbn em ratas wistar. 2009. 333 Departamento de Cirurgia, Universidade Federal dpo Ceará, Fortaleza.
DRAY, T. G.; HARDIN, N. J.; SOFFERMAN, R. A. Angiogenesis as a prognostic marker in early head and neck cancer. The Annals of otology, rhinology, and laryngology, v. 104, n. 9 Pt 1, p. 724-9, Sep 1995. ISSN 0003-4894 (Print) DUSE, A. O. et al. Mast cells contribute to the angiogenesis in non-Hodgkin lymphoma. An immunohistochemical study based on the relationship with
microvessel density. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, v. 52, n. 3 Suppl, p. 1091-6, 2011. ISSN 1220-0522 (Print)
EICHHORN, M. E. et al. Angiogenesis in cancer: molecular mechanisms, clinical impact. Langenbeck's archives of surgery / Deutsche Gesellschaft fur
Chirurgie, v. 392, n. 3, p. 371-9, May 2007. ISSN 1435-2443 (Print)
EINSPAHR, J. G. et al. Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression. Cancer, v. 110, n. 11, p. 2519-27, Dec 1 2007. ISSN 0008-543X (Print)
ELPEK, G. O. et al. The prognostic relevance of angiogenesis and mast cells in squamous cell carcinoma of the oesophagus. Journal of clinical pathology, v. 54, n. 12, p. 940-4, Dec 2001. ISSN 0021-9746 (Print)
EROVIC, B. M. et al. Quantitation of microvessel density in squamous cell carcinoma of the head and neck by computer-aided image analysis. Wiener
FECHINE-JAMACARU, F. V. Quantificação de angiogênese corneana in vivo através de processamento de imagens digitais. 2006. 292 Tese de Doutorado Departamento de Cirurgia Universidade Federal do Ceará, Fortaleza.
FENG, C. W. et al. Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features. BMC cancer, v. 2, p. 8, Apr 29 2002. ISSN 1471-2407
(Electronic)
FOLKMAN, J. Tumor angiogenesis: therapeutic implications. The New England journal of medicine, v. 285, n. 21, p. 1182-6, Nov 18 1971. ISSN 0028-4793 (Print) ______. What is the evidence that tumors are angiogenesis dependent? Journal of the National Cancer Institute, v. 82, n. 1, p. 4-6, Jan 3 1990. ISSN 0027-8874 (Print)
FOLKMAN, J. et al. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature, v. 339, n. 6219, p. 58-61, May 4 1989. ISSN 0028-0836 (Print) FOX, S. B.; GATTER, K. C.; HARRIS, A. L. Tumour angiogenesis. The Journal of pathology, v. 179, n. 3, p. 232-7, Jul 1996. ISSN 0022-3417 (Print)
FOX, S. B. et al. Tumor angiogenesis in node-negative breast carcinomas--
relationship with epidermal growth factor receptor, estrogen receptor, and survival. Breast cancer research and treatment, v. 29, n. 1, p. 109-16, Jan 1994. ISSN 0167-6806 (Print)
GALLO, O. et al. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer. Journal of the National Cancer Institute, v. 90, n. 8, p. 587-96, Apr 15 1998. ISSN 0027-8874 (Print)
GASPARINI, G. et al. Intratumoral microvessel density and p53 protein: correlation with metastasis in head-and-neck squamous-cell carcinoma. International journal of cancer. Journal international du cancer, v. 55, n. 5, p. 739-44, Nov 11 1993. ISSN 0020-7136 (Print)
GLEICH, L. L. et al. Tumor angiogenesis as a prognostic indicator in T2-T4 oral cavity squamous cell carcinoma: a clinical-pathologic correlation. Head & neck, v. 19, n. 4, p. 276-80, Jul 1997. ISSN 1043-3074 (Print)
GLEICH, L. L. et al. Tumor angiogenesis in T1 oral cavity squamous cell carcinoma: role in predicting tumor aggressiveness. Head & neck, v. 18, n. 4, p. 343-6, Jul-Aug 1996. ISSN 1043-3074 (Print)
GOKSU EROL, A. Y. et al. The role of mast cells and angiogenesis in benign and malignant neoplasms of the uterus. Pathology, research and practice, v. 207, n. 10, p. 618-22, Oct 15 2011. ISSN 1618-0631 (Electronic)
GRAHAM, C. H. et al. Extent of vascularization as a prognostic indicator in thin (< 0.76 mm) malignant melanomas. The American journal of pathology, v. 145, n. 3, p. 510-4, Sep 1994. ISSN 0002-9440 (Print)
HEGDE, P. U. et al. Tumor angiogenesis and p53 mutations: prognosis in head and neck cancer. Archives of otolaryngology--head & neck surgery, v. 124, n. 1, p. 80-5, Jan 1998. ISSN 0886-4470 (Print)
IAMAROON, A. et al. Increase of mast cells and tumor angiogenesis in oral squamous cell carcinoma. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the
American Academy of Oral Pathology, v. 32, n. 4, p. 195-9, Apr 2003. ISSN 0904- 2512 (Print)
JAHANSHAHI, G.; SABAGHIAN, M. Comparative immunohistochemical analysis of angiogenesis and mast cell density in oral normal mucosa and squamous cell carcinoma. Dental research journal, v. 9, n. 1, p. 8-12, Jan 2012. ISSN 2008-0255 (Electronic)
KALRA, M. et al. The role of mast cells on angiogenesis in oral squamous cell carcinoma. Medicina oral, patologia oral y cirugia bucal, v. 17, n. 2, p. e190-6, 2012. ISSN 1698-6946 (Electronic)
KAYASELCUK, F. et al. The expression of survivin and Ki-67 in meningiomas: correlation with grade and clinical outcome. J Neurooncol, v. 67, n. 1-2, p. 209-14, Mar-Apr 2004.
KLIJANIENKO, J. et al. Tumor vascularization, mitotic index, histopathologic grade, and DNA ploidy in the assessment of 114 head and neck squamous cell carcinomas. Cancer, v. 75, n. 7, p. 1649-56, Apr 1 1995. ISSN 0008-543X (Print)
LEEDY, D. A. et al. Tumor angiogenesis, the p53 antigen, and cervical metastasis in squamous carcinoma of the tongue. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, v. 111, n. 4, p. 417-22, Oct 1994. ISSN 0194-5998 (Print)
MAAHS, G. S. Fator Tecidual e Densidade Microvascular como Fatores
Preditivos de metástases Ganglionares no Carcinoma Epidermóide de Boca. 2008. Faculdade de Medicina da Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre.
MACCHIARINI, P. et al. Relation of neovascularisation to metastasis of non-small- cell lung cancer. Lancet, v. 340, n. 8812, p. 145-6, Jul 18 1992. ISSN 0140-6736 (Print)
MACLUSKEY, M. et al. Apoptosis, proliferation, and angiogenesis in oral tissues. Possible relevance to tumour progression. The Journal of pathology, v. 191, n. 4, p. 368-75, Aug 2000. ISSN 0022-3417 (Print)
MAEDA, T. et al. Expression of vascular endothelial growth factor in human oral squamous cell carcinoma: its association with tumour progression and p53 gene status. J Clin Pathol, v. 51, n. 10, p. 771-5, Oct 1998.
MICHAILIDOU, E. Z.; MARKOPOULOS, A. K.; ANTONIADES, D. Z. Mast cells and angiogenesis in oral malignant and premalignant lesions. The open dentistry journal, v. 2, p. 126-32, 2008. ISSN 1874-2106 (Electronic).
MIDDLETON, J. et al. A comparative study of endothelial cell markers expressed in chronically inflamed human tissues: MECA-79, Duffy antigen receptor for
chemokines, von Willebrand factor, CD31, CD34, CD105 and CD146. The Journal of pathology, v. 206, n. 3, p. 260-8, Jul 2005. ISSN 0022-3417 (Print)
MOHTASHAM, N. et al. Mast cell density and angiogenesis in oral dysplastic epithelium and low- and high-grade oral squamous cell carcinoma. Acta
odontologica Scandinavica, v. 68, n. 5, p. 300-4, Sep 2010. ISSN 1502-3850 (Electronic)
OLIVEIRA-NETO, H. H. et al. Decrease in mast cells in oral squamous cell
carcinoma: possible failure in the migration of these cells. Oral oncology, v. 43, n. 5, p. 484-90, May 2007. ISSN 1368-8375 (Print)
PARUMS, D. V. et al. JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. Journal of clinical pathology, v. 43, n. 9, p. 752-7, Sep 1990. ISSN 0021-9746 (Print)
PAZOUKI, S. et al. The association between tumour progression and vascularity in the oral mucosa. The Journal of pathology, v. 183, n. 1, p. 39-43, Sep 1997. ISSN 0022-3417 (Print)
PEREZ, R. S. et al. Estudo Epidemiológico do Carcinoma Espinocelular da Boca e Orofaringe. Arq. Int. Otorrinolaringol., v. 11, n. 3, p. 271-277, 2007.
POON, R. T.; FAN, S. T.; WONG, J. Clinical implications of circulating angiogenic factors in cancer patients. J Clin Oncol, v. 19, n. 4, p. 1207-25, Feb 15 2001. Disponível em: <
PRADO, S. M. et al. Evaluation of COX-2, EGFR, and p53 as biomarkers of non- dysplastic oral leukoplakias. Experimental and molecular pathology, v. 89, n. 2, p. 197-203, Oct 2010. ISSN 1096-0945 (Electronic)
RIBATTI, D.; VACCA, A.; DAMMACCO, F. The role of the vascular phase in solid tumor growth: a historical review. Neoplasia, v. 1, n. 4, p. 293-302, Oct 1999. ISSN 1522-8002 (Print)
SAUTER, E. R. et al. Vascular endothelial growth factor is a marker of tumor
invasion and metastasis in squamous cell carcinomas of the head and neck. Clinical cancer research : an official journal of the American Association for Cancer Research, v. 5, n. 4, p. 775-82, Apr 1999. ISSN 1078-0432 (Print)
SCHLINGEMANN, R. O. et al. Leukocyte antigen CD34 is expressed by a subset of cultured endothelial cells and on endothelial abluminal microprocesses in the tumor stroma. Laboratory investigation; a journal of technical methods and pathology, v. 62, n. 6, p. 690-6, Jun 1990. ISSN 0023-6837 (Print)
SHARMA, B. et al. Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma. Indian journal of dental research : official
publication of Indian Society for Dental Research, v. 21, n. 2, p. 260-5, Apr-Jun 2010. ISSN 1998-3603 (Electronic)
SIDDIQUI, G. K. et al. Prognostic significance of intratumoral vascular endothelial growth factor as a marker of tumour angiogenesis in epithelial ovarian cancer. Eur J Gynaecol Oncol, v. 31, n. 2, p. 156-9.
SMITH-MCCUNE, K. K.; WEIDNER, N. Demonstration and characterization of the angiogenic properties of cervical dysplasia. Cancer research, v. 54, n. 3, p. 800-4, Feb 1 1994. ISSN 0008-5472 (Print)
SOUZA, G. F. M.; FREITAS, R. A.; MIRANDA, J. L. Angiogênese em carcinoma de células escamosas de língua e lábio inferior. Cienc. Odontol. Bras., v. 10, n. 1, p. 12-18, Jan-Mar 2007.
TERMAN, B. I.; STOLETOV, K. V. VEGF and Tumor Angiogenesis. Einstein Quart. J. Biol. and Med., v. 18, p. 59-66, 2001.
THEOHARIDES, T. C.; CONTI, P. Mast cells: the Jekyll and Hyde of tumor growth. Trends in immunology, v. 25, n. 5, p. 235-41, May 2004. ISSN 1471-4906 (Print) TIPOE, G. L.; JIN, Y.; WHITE, F. H. The relationship between vascularity and cell proliferation in human normal and pathological lesions of the oral cheek epithelium. European journal of cancer. Part B, Oral oncology, v. 32B, n. 1, p. 24-31, Jan 1996. ISSN 0964-1955 (Print)
TOMITA, M.; MATSUZAKI, Y.; ONITSUKA, T. Effect of mast cells on tumor
angiogenesis in lung cancer. The Annals of thoracic surgery, v. 69, n. 6, p. 1686- 90, Jun 2000. ISSN 0003-4975 (Print)
TUNA, B. et al. Association of mast cells with microvessel density in renal cell carcinomas. European urology, v. 50, n. 3, p. 530-4, Sep 2006. ISSN 0302-2838 (Print)
VERMEULEN, P. B. et al. Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation. European journal of cancer, v. 32A, n. 14, p. 2474-84, Dec 1996. ISSN 0959-8049 (Print) WEIDNER, N. Intratumor microvessel density as a prognostic factor in cancer. The American journal of pathology, v. 147, n. 1, p. 9-19, Jul 1995. ISSN 0002-9440 (Print)
WEIDNER, N. et al. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. The American journal of pathology, v. 143, n. 2, p. 401-9, Aug 1993. ISSN 0002-9440 (Print)
WILLIAMS, J. K. et al. Tumor angiogenesis as a prognostic factor in oral cavity tumors. American journal of surgery, v. 168, n. 5, p. 373-80, Nov 1994. ISSN 0002- 9610 (Print)