5 Discussion
5.2 The analysis seen in the light of the Mathematical tasks of teaching
1. O ferro é um elemento essencial para a expressão dos genes IFN-γ, TNF-α, IL-6, MIG e IP10 em CMSP humanas frente à estimulação por antígeno de L. infantum.
2. O ferro aumenta a produção de IFN- , TNF-α e IL-10 em linfócitos T humanos estimulados por antígeno de L. infantum, porém um efeito oposto é encontrado em monócitos, onde o mesmo metal inibiu a produção de TNF- α, IL-6 e IL-10, sugerindo um papel imunomodulatório para o ferro sobre células mononucleares.
3. Em caninos naturalmente infectados por L. infantum, a alta carga parasitária esplênica implica em aumento na expressão de IRP2 e IL-10 e redução na expressão gênica de IFN-γ e TNF-α no baço, além de elevada produção de anticorpos anti-Leishmania do tipo IgG2.
4. O nível sistêmico e intracelular de ferro pode ser um fator determinante para a elaboração de uma resposta imune eficaz na infecção por L. infantum.
63
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