Kynurenine Pathway Metabolites in Alzheimer’s Disease

We investigated cross-sectional associations between reported intake of fish and omega-3 (n-3) long-chain PUFA (LC- PUFA) and plasma metabolites related to the kynurenine

4 Abbreviations used: AA, anthranilic acid; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; GAM, generalized additive model; HAA,

Methods: We compared serum levels of tryptophan and the seven tryptophan metabolites kynurenine, kynurenic acid, anthranilic acid, 3‑hydroxykynurenine, xanthurenic

AA, anthranilic acid; BMI, body mass index; COWAT, Controlled Oral Word Association Test; Dia, diabetes; DST, Digit Symbol Test; Edu, education; GFR, glomerular filtration rate;

Interestingly, our study showed that associations between higher levels of KYN, 3-HK, KA, XA, 3-HAA and lower odds for cognitive impairment were more pronounced in participants

We aimed to evaluate 10 biomarkers related to inflammation and the kynurenine pathway, including neopterin, kynurenine:tryptophan ratio, C-reactive protein, tryptophan, and