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Infeksjonsmedisinsk seksjon, Infeksjonsmedisinsk seksjon,

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(1)

HIV – nyere viten

Vegard Skogen

Infeksjonsmedisinsk seksjon, Infeksjonsmedisinsk seksjon,

UNN & UiT

(2)

Jeg er ikke redd for mikrober ! Tanja 4 år

Jeg er ikke redd for mikrober ! Tanja 4 år

(3)

Jeg var veldig syk-men nå er jeg frisk! Vova 5 år

(4)

1981

(5)

UNAIDS 2011

(6)

Take the ART daily! Diagnose and treat!

Moving from death sentence to chronic disease management

The Strategies for Management of Antiretroviral Therapy (SMART) Study Group. NEJM 2006

The INSIGHT START Study Group. NEJM 2015

(7)

Updated results from the Danish HIV Cohort study indicates (with many others) that survival of persons under optimal care with HIV infection approaches that of uninfected persons.

Lohse N et al. Ann Intern Med. 2016;165(10):749-750

(8)

Treatment as

Prevention (TasP)

The HPTN 052 study The HPTN 052 study demonstrated a 96%

reduction in HIV transmission in discordant couples using antiretroviral therapy (ART).

Rodger AJ et al. JAMA 2016

Cohen MS et al NEJM 2011

1/28 linked

transmissions occured in the early therapy

group The Partner 2 study presented at IAS 2018 by Rodger AJ et al:

The chance of any HIV-positive person with an undetectable viral load transmitting the virus to a sexual partner is

scientifically equivalent to zero.

Undetectable equals Untransmittable (U=U)

(9)

Levi J et al. IAS 2015

(10)

Lazarus JV et al BMC Medicine 2016

University Hospital of North Norway Dec 31st 2017:

On treatment: 96%

Viral supressed: 95%

Ranveig Langseth. Master thesis (MPH). UiT 2018

(11)
(12)

Sarah B. Laskey & Robert F. Siliciano. Nature Reviews Microbiology 2014; (12): 772–780

(13)

ART

Faglige retningslinjer for oppfølging og behandling av hiv 2015

(14)

Fra blå- til H-resept for HIV H

(15)
(16)
(17)

Interaksjoner

(18)

Riddell J et al. JAMA 2018

(19)

Volk JE et al CID 2015

(20)

http://www.starobserver.com.au/news/norway-becomes-first-country-offer-free-prep

(21)

Faglige retningslinjer for oppfølging og behandling av hiv infeksjon i Norge 2018

(22)

Faglige retningslinjer for oppfølging og behandling av hiv infeksjon i Norge 2018

(23)

CID 2015;60(S3):S165-9

(24)

Rapidly declining HIV infection in MSM in central London

Large increase in HIV tests Test and treat program

PrEP/PEP

STD screening

Nwokola N et al. Lancet 2017

(25)

Referanser

Last ned nå ( PDF - 25 sider - 7.06 MB )

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