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Supplementary Figure 1: QOL10

Global subscale Social subscale

How do you consider your mental health at the moment?

(1) very poor (2) poor

(3) neither good nor poor (4) good

(5) very good

How do you consider your social functioning at the moment?

(1) very poor (2) poor

(3) neither good nor poor (4) good

(5) very good How would you assess your quality of your

life now?

(1) very poor (2) poor

(3) neither good nor poor (4) good

(5) very good

How do you consider your ability to love at the moment?

(1) very poor (2) poor

(3) neither good nor poor (4) good

(5) very good How do you consider your physical health at

the moment?

(1) very poor (2) poor

(3) neither good nor poor (4) good

(5) very good

How are your relationships with your friends at the moment?

(1) very poor (2) poor

(3) neither good nor poor (4) good

(5) very good How do you feel about yourself at the

moment?

(1) very poor (2) poor

(3) neither good nor poor (4) good

(5) very good

How do you consider your sexual functioning at the moment?

(1) very poor (2) poor

(3) neither good nor poor (4) good

(5) very good How is your working ability at the moment?

(1) very poor (2) poor

(3) neither good nor poor (4) good

(5) very good

How is your relationship with your partner at the moment?

(1) very poor (2) poor

(3) neither good nor poor (4) good

(5) very good QoL: quality of life

Supplementary Figure 1 legend: The five items in each of the QOL10’s global and social subscales.

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Supplementary Figure 2: Quality of life of opioid maintenance treatment subgroup

* Change exceeded the minimum clinically important difference (MCID). OMT: opioid maintenance treatment. QoL: quality of life.

Main effects of time: Fig 2a: F(1, 158)=1, p=0.284; Fig 2b: F(1, 8)=1, p=0.301. Interaction effect of time and treatment: Fig 2a: F(1, 158)=9, p=0.004. Interaction effect of time and social network: Fig 2b: F(3, 8)=0.4, p=0.779.

Supplementary Figure 2 legend: In a subgroup analysis of participants who began in OMT, social QoL improved over time only for those who remained in treatment. The most precipitous decline was reported by those who had dropped out of treatment and maintained a substance-using network.

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