O vírus fixo CVS e o isolado do morcego L. ega, inoculados em hamsters e camundongos, apresentaram comportamento biológico compatível com o descrito na literatura para o vírus da raiva.
O isolado de L. ega produziu raiva furiosa em hamsters e camundongos, enquanto que o vírus CVS causou raiva paralítica.
O isolado de L. ega conseguiu provocar raiva em hamsters e camundongos, quando inoculados pela via intramuscular e intranasal, apresentando comportamento biológico diferente em relação ao vírus CVS, caracterizado por uma menor mortalidade.
Com o vírus CVS, a via de inoculação intranasal produziu períodos de incubação e clínicos mais prolongados.
Pelos estudos filogenéticos do Gene N e G, o isolado de L. ega está relacionado com outras linhagens procedentes de morcegos do gênero Lassiurus das Américas e que pertence ao Genótipo 1.
Com o isolado do L. ega, as principais substituções foram encontradas na sequencia de aminoácidos da glicoproteína G envolvendo os sitios antigênicos AI, AII e no domínio de fusão dependente do baixo pH, enquanto que o vírus CVS não apresentou semelhantes alterações.
.
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APÊNDICE
Resultados analise estatístico no Minitab Results for: Worksheet 2
Kruskal-Wallis Test: Período de incubação versus Via de administracao Kruskal-Wallis Test on Período de incubação
Via de
administracao N Median Ave Rank Z 42 6,000 30,9 -5,06
2 31 7,000 49,8 0,98 3 18 9,000 74,8 5,17 Overall 91 46,0 H = 35,82 DF = 2 P = 0,000
H = 37,38 DF = 2 P = 0,000 (adjusted for ties)
Kruskal-Wallis Test: Período clínico versus Via de administracao
Kruskal-Wallis Test on Período clínico Via de
administracao N Median Ave Rank Z 1 42 3,000 39,0 -2,33
2 31 4,000 47,0 0,25 3 18 6,000 60,6 2,62 Overall 91 46,0 H = 8,48 DF = 2 P = 0,014
H = 8,68 DF = 2 P = 0,013 (adjusted for ties)
Kruskal-Wallis Test: Período de incubação (días) versus VIRUS
82 cases were used
Incubation period L. ega versus CVS 1 cases contained missing values
Kruskal-Wallis Test on Período de incubação (días) VIRUS N Median Ave Rank Z
2 10 12,000 70,2 4,06 3 72 7,500 37,5 -4,06 Overall 82 41,5 H = 16,48 DF = 1 P = 0,000
H = 16,79 DF = 1 P = 0,000 (adjusted for ties)
Kruskal-Wallis Test: Período clínico (días) versus VIRUS 82 cases were used
1 cases contained missing values
Kruskal-Wallis Test on Período clínico (días) VIRUS N Median Ave Rank Z 2 10 3,000 41,5 0,01 3 72 3,000 41,5 -0,01 Overall 82 41,5 H = 0,00 DF = 1 P = 0,994
H = 0,00 DF = 1 P = 0,994 (adjusted for ties)
Descriptive Statistics: Período de incubação. Período clínico
Variable N N* Mean SE Mean StDev Variance CoefVar Minimum Período de incubação 83 0 6,651 0,170 1,549 2,401 23,30 5,000 Período clínico 83 0 4,386 0,221 2,011 4,045 45,86 1,000 N for
.
Variable Q1 Median Q3 Maximum IQR Mode Mode Período de incubação 5,000 6,000 7,000 13,000 2,000 5 23 Período clínico 3,000 4,000 6,000 9,000 3,000 3 19
Descriptive Statistics: Período de incubação (dí. Período clínico (días) v
Variable N N* Mean SE Mean StDev Variance CoefVar Período de incubação (dí 42 0 6,048 0,223 1,447 2,095 23,93 Período clínico (días) v 42 0 4,167 0,379 2,459 6,045 59,01 Variable Minimum Q1 Median Q3 Maximum IQR Mode Período de incubação (dí 5,000 5,000 6,000 6,250 13,000 1,250 5 Período clínico (días) v 1,000 2,000 3,000 5,500 9,000 3,500 3 N for
Variable Mode Período de incubação (dí 17 Período clínico (días) v 12
Kruskal-Wallis Test: Período de incubação versus Via de administracao Kruskal-Wallis Test on Período de incubação
Via de
administracao N Median Ave Rank Z 1 42 6,000 30,9 -5,06
2 31 7,000 49,8 0,98 3 18 9,000 74,8 5,17 Overall 91 46,0 H = 35,82 DF = 2 P = 0,000
H = 37,38 DF = 2 P = 0,000 (adjusted for ties)
Kruskal-Wallis Test: Período clínico versus Via de administracao
Kruskal-Wallis Test on Período clínico Via de
administracao N Median Ave Rank Z 1 42 3,000 39,0 -2,33