3.2 Laboratory analyses
3.2.3 Optically stimulated luminescence
1. Sintomas de tronco encefálico são frequentes manifestações do NMOSD. Uma grande variedade de STE pode ser encontrada, no entanto, predominam os sintomas da síndrome da área postrema (náuseas, vômitos e soluços intratáveis), a vertigem, e a diplopia por diferentes distúrbios da motilidade ocular.
2. Pacientes com NMOSD, soropositivos e soronegativos para o anticorpo anti-AQP4 apresentam STE em frequências semelhantes. No entanto, náuseas, vômitos e soluços intratáveis, e sintomas trigeminais foram encontrados em frequência significativamente maior nos pacientes soropositivos.
3. Os STE podem preceder, se associar ou ocorrer após a NO e a mielite. Náuseas, vômitos e soluços intratáveis mais frequentemente ocorrem como manifestação inicial da doença, seja isoladamente, seja em associação com a NO ou a mielite.
4. A presença da síndrome da área postrema, particularmente precedendo ou em associação com perda visual ou sintomas de mielite, deve alertar os clínicos quanto ao possível diagnóstico de NMOSD, justificando propedêutica apropriada, e se positiva, tratamento imediato da doença.
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