Concluiu-se que a administração de cumarina é capaz de reverter o comportamento tipo depressivo, induzido pela administração repetida de corticosterona. Os efeitos antidepressivos da cumarina ocorreram pelos mecanismos serotoninérgicos e noradrenérgicos, além do envolvimento da ação antioxidante e anti-inflamatória deste composto.
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