442
The authors reported no potential conflict of interest.
443
Funding
444
This work was supported by the Research Council of Norway [grant number 228874], the 445
South-Eastern Norway Regional Health Authority, and the University of Oslo.
446
24
References
447
1. Garralda ME, Chalder T. Practitioner review: Chronic fatigue syndrome in childhood. J 448
Child Psychol Psyc. 2005;46(11):1143-51. doi: 10.1111/j.1469-7610.2005.01424.x. PubMed PMID:
449
WOS:000232658700002.
450
2. Mackenzie C, Wray A. Chronic Fatigue Syndrome in children and young people. Paediatrics 451
and Child Health. 2013;23(1):35-9.
452
3. Nijhof S, Maijer K, Bleijenberg G, Uiterwaal CS, Kimpen JL, van de Putte EM. Adolescent 453
chronic fatigue syndrome: prevalence, incidence, and morbidity. Pediatrics. 2011;127(5):e1169-75.
454
doi: 10.1542/peds.2010-1147. PubMed PMID: 21502228.
455
4. Crawley EM, Emond AM, Sterne JA. Unidentified Chronic Fatigue Syndrome/myalgic 456
encephalomyelitis (CFS/ME) is a major cause of school absence: surveillance outcomes from 457
school-based clinics. BMJ open. 2011;1(2):e000252. doi: 10.1136/bmjopen-2011-000252. PubMed 458
PMID: 22155938; PubMed Central PMCID: PMCPMC3244656.
459
5. IOM. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness.
460
In: Medicine Io, editor. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining 461
an Illness. Washington (DC): The National Academies Press2015.
462
6. Wyller VB, Barbieri R, Saul JP. Blood pressure variability and closed-loop baroreflex 463
assessment in adolescent chronic fatigue syndrome during supine rest and orthostatic stress. Eur J 464
Appl Physiol. 2011;111(3):497-507. doi: 10.1007/s00421-010-1670-9. PubMed PMID: 20890710;
465
PubMed Central PMCID: PMCPMC3037975.
466
7. Tanaka M, Ishii A, Watanabe Y. Neural mechanisms underlying chronic fatigue. Rev 467
Neurosci. 2013;24(6):617-28. doi: 10.1515/revneuro-2013-0035. PubMed PMID: 24114898.
468
8. Nijs J, Meeus M, Van Oosterwijck J, Ickmans K, Moorkens G, Hans G, et al. In the mind or in 469
the brain? Scientific evidence for central sensitisation in chronic fatigue syndrome. Eur J Clin Invest.
470
2012;42(2):203-12. doi: 10.1111/j.1365-2362.2011.02575.x. PubMed PMID: 21793823.
471
9. Nijhof S, Rutten JM, Uiterwaal CS, Bleijenberg G, Kimpen JL, van de Putte EM. The role of 472
hypocortisolism in chronic fatigue syndrome. Psychoneuroendocrinology. 2014;42:199-206.
473
10. Papadopoulos AS, Cleare AJ. Hypothalamic-pituitary-adrenal axis dysfunction in chronic 474
fatigue syndrome. Nat Rev Endocrinol. 2012;8(1):22-32. doi: 10.1038/nrendo.2011.153. PubMed 475
PMID: 21946893.
476
11. Wyller VB, Vitelli V, Sulheim D, Fagermoen E, Winger A, Godang K, et al. Altered 477
neuroendocrine control and association to clinical symptoms in adolescent chronic fatigue 478
syndrome: a cross-sectional study. J Transl Med. 2016;14(1):121. doi: 10.1186/s12967-016-0873-1.
479
PubMed PMID: 27149955; PubMed Central PMCID: PMCPMC4858924.
480
12. Wyller VB, Eriksen HR, Malterud K. Can sustained arousal explain the Chronic Fatigue 481
Syndrome? Behavioral and brain functions : BBF. 2009;5:10. doi: 10.1186/1744-9081-5-10.
482
PubMed PMID: 19236717; PubMed Central PMCID: PMC2654901.
483
13. Wortinger LA, Endestad T, Melinder AM, Oie MG, Sevenius A, Bruun Wyller V. Aberrant 484
Resting-State Functional Connectivity in the Salience Network of Adolescent Chronic Fatigue 485
Syndrome. Plos One. 2016;11(7):e0159351. doi: 10.1371/journal.pone.0159351. PubMed PMID:
486
27414048.
487
25 14. Critchley HD. The human cortex responds to an interoceptive challenge. Proc Natl Acad Sci 488
U S A. 2004;101(17):6333-4. doi: 10.1073/pnas.0401510101. PubMed PMID: 15096592; PubMed 489
Central PMCID: PMCPMC404044.
490
15. Craig AD. How do you feel--now? The anterior insula and human awareness. Nat Rev 491
Neurosci. 2009;10(1):59-70. doi: 10.1038/nrn2555. PubMed PMID: 19096369.
492
16. Critchley HD, Wiens S, Rotshtein P, Ohman A, Dolan RJ. Neural systems supporting 493
interoceptive awareness. Nat Neurosci. 2004;7(2):189-95. doi: 10.1038/nn1176. PubMed PMID:
494
14730305.
495
17. Craig AD. Significance of the insula for the evolution of human awareness of feelings from 496
the body. Ann N Y Acad Sci. 2011;1225:72-82. doi: 10.1111/j.1749-6632.2011.05990.x. PubMed 497
PMID: 21534994.
498
18. Sridharan D, Levitin DJ, Menon V. A critical role for the right fronto-insular cortex in 499
switching between central-executive and default-mode networks. Proc Natl Acad Sci U S A.
500
2008;105(34):12569-74. doi: 10.1073/pnas.0800005105. PubMed PMID: 18723676; PubMed 501
Central PMCID: PMCPMC2527952.
502
19. Uddin LQ, Supekar KS, Ryali S, Menon V. Dynamic reconfiguration of structural and 503
functional connectivity across core neurocognitive brain networks with development. J Neurosci.
504
2011;31(50):18578-89. doi: 10.1523/JNEUROSCI.4465-11.2011. PubMed PMID: 22171056;
505
PubMed Central PMCID: PMCPMC3641286.
506
20. Supekar K, Menon V. Developmental maturation of dynamic causal control signals in 507
higher-order cognition: a neurocognitive network model. PLoS Comput Biol. 2012;8(2):e1002374.
508
doi: 10.1371/journal.pcbi.1002374. PubMed PMID: 22319436; PubMed Central PMCID:
509
PMCPMC3271018.
510
21. Menon V, Uddin LQ. Saliency, switching, attention and control: a network model of insula 511
function. Brain Struct Funct. 2010;214(5-6):655-67. doi: 10.1007/s00429-010-0262-0. PubMed 512
PMID: 20512370; PubMed Central PMCID: PMCPMC2899886.
513
22. D'Esposito M. From cognitive to neural models of working memory. Philos Trans R Soc 514
Lond B Biol Sci. 2007;362(1481):761-72. doi: 10.1098/rstb.2007.2086. PubMed PMID: 17400538;
515
PubMed Central PMCID: PMCPMC2429995.
516
23. Fuster JM. Executive frontal functions. Exp Brain Res. 2000;133(1):66-70. PubMed PMID:
517
10933211.
518
24. Miller EK, Cohen JD. An integrative theory of prefrontal cortex function. Annu Rev 519
Neurosci. 2001;24:167-202. doi: 10.1146/annurev.neuro.24.1.167. PubMed PMID: 11283309.
520
25. Smith EE, Jonides J. Neuroimaging analyses of human working memory. P Natl Acad Sci 521
USA. 1998;95(20):12061-8. PubMed PMID: WOS:000076222200099.
522
26. GoldmanRakic PS. Architecture of the prefrontal cortex and the central executive. Ann Ny 523
Acad Sci. 1995;769:71-83. PubMed PMID: WOS:A1995BE92F00006.
524
27. Napadow V, LaCount L, Park K, As-Sanie S, Clauw DJ, Harris RE. Intrinsic brain connectivity 525
in fibromyalgia is associated with chronic pain intensity. Arthritis Rheum. 2010;62(8):2545-55. doi:
526
10.1002/art.27497. PubMed PMID: 20506181; PubMed Central PMCID: PMCPMC2921024.
527
28. Baliki MN, Apkarian AV. Nociception, Pain, Negative Moods, and Behavior Selection.
528
Neuron. 2015;87(3):474-91. doi: 10.1016/j.neuron.2015.06.005. PubMed PMID: 26247858;
529
PubMed Central PMCID: PMCPMC4529956.
530
29. Baliki MN, Geha PY, Fields HL, Apkarian AV. Predicting value of pain and analgesia: nucleus 531
accumbens response to noxious stimuli changes in the presence of chronic pain. Neuron.
532
26 2010;66(1):149-60. doi: 10.1016/j.neuron.2010.03.002. PubMed PMID: 20399736; PubMed
533
Central PMCID: PMCPMC2873199.
534
30. Baliki MN, Petre B, Torbey S, Herrmann KM, Huang L, Schnitzer TJ, et al. Corticostriatal 535
functional connectivity predicts transition to chronic back pain. Nat Neurosci. 2012;15(8):1117-9.
536
doi: 10.1038/nn.3153. PubMed PMID: 22751038; PubMed Central PMCID: PMCPMC3411898.
537
31. Mansour AR, Baliki MN, Huang L, Torbey S, Herrmann KM, Schnitzer TJ, et al. Brain white 538
matter structural properties predict transition to chronic pain. Pain. 2013;154(10):2160-8. doi:
539
10.1016/j.pain.2013.06.044. PubMed PMID: 24040975; PubMed Central PMCID: PMCPMC3799881.
540
32. Weng Y, Qi R, Liu C, Ke J, Xu Q, Wang F, et al. Disrupted functional connectivity density in 541
irritable bowel syndrome patients. Brain Imaging Behav. 2016. doi: 10.1007/s11682-016-9653-z.
542
PubMed PMID: 27848148.
543
33. Liu X, Silverman A, Kern M, Ward BD, Li SJ, Shaker R, et al. Excessive coupling of the 544
salience network with intrinsic neurocognitive brain networks during rectal distension in 545
adolescents with irritable bowel syndrome: a preliminary report. Neurogastroenterol Motil.
546
2016;28(1):43-53. doi: 10.1111/nmo.12695. PubMed PMID: 26467966; PubMed Central PMCID:
547
PMCPMC4688218.
548
34. Wiebking C, de Greck M, Duncan NW, Tempelmann C, Bajbouj M, Northoff G.
549
Interoception in insula subregions as a possible state marker for depression-an exploratory fMRI 550
study investigating healthy, depressed and remitted participants. Front Behav Neurosci. 2015;9:82.
551
doi: 10.3389/fnbeh.2015.00082. PubMed PMID: 25914633; PubMed Central PMCID:
552
PMCPMC4392695.
553
35. McGrath CL, Kelley ME, Holtzheimer PE, Dunlop BW, Craighead WE, Franco AR, et al.
554
Toward a neuroimaging treatment selection biomarker for major depressive disorder. JAMA 555
Psychiatry. 2013;70(8):821-9. doi: 10.1001/jamapsychiatry.2013.143. PubMed PMID: 23760393;
556
PubMed Central PMCID: PMCPMC4413467.
557
36. Gay CW, Robinson ME, Lai S, O'Shea A, Craggs JG, Price DD, et al. Abnormal Resting-State 558
Functional Connectivity in Patients with Chronic Fatigue Syndrome: Results of Seed and Data-559
Driven Analyses. Brain Connect. 2015. doi: 10.1089/brain.2015.0366. PubMed PMID: 26449441.
560
37. Boissoneault J, Letzen J, Lai S, O'Shea A, Craggs J, Robinson ME, et al. Abnormal resting 561
state functional connectivity in patients with chronic fatigue syndrome: an arterial spin-labeling 562
fMRI study. Magn Reson Imaging. 2016;34(4):603-8. doi: 10.1016/j.mri.2015.12.008. PubMed 563
PMID: 26708036; PubMed Central PMCID: PMCPMC4801728.
564
38. Boissoneault J, Letzen J, Lai S, Robinson ME, Staud R. Static and dynamic functional 565
connectivity in patients with chronic fatigue syndrome: use of arterial spin labelling fMRI. Clin 566
Physiol Funct Imaging. 2016. doi: 10.1111/cpf.12393. PubMed PMID: 27678090.
567
39. Menon V. Salience Network. In: Toga AW, editor. Brain Mapping: An Encyclopedic 568
Reference. 2: Academic Press: Elsevier; 2015. p. 597-611.
569
40. Crossley NA, Mechelli A, Scott J, Carletti F, Fox PT, McGuire P, et al. The hubs of the human 570
connectome are generally implicated in the anatomy of brain disorders. Brain : a journal of 571
neurology. 2014;137(Pt 8):2382-95. doi: 10.1093/brain/awu132. PubMed PMID: 25057133;
572
PubMed Central PMCID: PMCPMC4107735.
573
41. Stam CJ. Modern network science of neurological disorders. Nat Rev Neurosci.
574
2014;15(10):683-95. doi: 10.1038/nrn3801. PubMed PMID: 25186238.
575
42. Barnden LR, Crouch B, Kwiatek R, Burnet R, Del Fante P. Evidence in chronic fatigue 576
syndrome for severity-dependent upregulation of prefrontal myelination that is independent of 577
27 anxiety and depression. NMR Biomed. 2015;28(3):404-13. doi: 10.1002/nbm.3261. PubMed PMID:
578
25702943; PubMed Central PMCID: PMCPMC4369127.
579
43. Barnden LR, Kwiatek R, Crouch B, Burnet R, Del Fante P. Autonomic correlations with MRI 580
are abnormal in the brainstem vasomotor centre in Chronic Fatigue Syndrome. Neuroimage Clin.
581
2016;11:530-7. doi: 10.1016/j.nicl.2016.03.017. PubMed PMID: 27114901; PubMed Central PMCID:
582
PMCPMC4833047.
583
44. Sulheim D, Fagermoen E, Sivertsen OS, Winger A, Wyller VB, Oie MG. Cognitive 584
dysfunction in adolescents with chronic fatigue: a cross-sectional study. Arch Dis Child. 2015. doi:
585
10.1136/archdischild-2014-306764. PubMed PMID: 25791841.
586
45. Winger A, Kvarstein G, Wyller VB, Sulheim D, Fagermoen E, Smastuen MC, et al. Pain and 587
pressure pain thresholds in adolescents with chronic fatigue syndrome and healthy controls: a 588
cross-sectional study. BMJ open. 2014;4(9):e005920. doi: 10.1136/bmjopen-2014-005920.
589
PubMed PMID: 25287104; PubMed Central PMCID: PMCPMC4187660.
590
46. Sulheim D, Fagermoen E, Winger A, Andersen AM, Godang K, Muller F, et al. Disease 591
mechanisms and clonidine treatment in adolescent chronic fatigue syndrome: a combined cross-592
sectional and randomized clinical trial. JAMA pediatrics. 2014;168(4):351-60. doi:
593
10.1001/jamapediatrics.2013.4647. PubMed PMID: 24493300.
594
47. Voss MW, Chaddock L, Kim JS, Vanpatter M, Pontifex MB, Raine LB, et al. Aerobic fitness is 595
associated with greater efficiency of the network underlying cognitive control in preadolescent 596
children. Neuroscience. 2011;199:166-76. doi: 10.1016/j.neuroscience.2011.10.009. PubMed 597
PMID: 22027235; PubMed Central PMCID: PMCPMC3237764.
598
48. Voss MW, Nagamatsu LS, Liu-Ambrose T, Kramer AF. Exercise, brain, and cognition across 599
the life span. J Appl Physiol (1985). 2011;111(5):1505-13. doi: 10.1152/japplphysiol.00210.2011.
600
PubMed PMID: 21527670; PubMed Central PMCID: PMCPMC3220305.
601
49. Erickson, Hillman CH, Kramer AF. Physical activity, brain, and cognition. Current Opinion in 602
Behavioral Sciences. 2015;4:27-32.
603
50. Evidence based guidelines for the management of CFS/ME (Chronic Fatigue 604
Syndrome/Myalgic Encephalopathy) in Children and Young Adults [Internet]. Royal College of 605
Paediatrics and Child Health. 2004.
606
51. Chronic fatigue syndrome/myalgic encephalomyelitis (or encephalopathy): Diagnosis and 607
management of CFS/ME in adults and children:NICE clinical guideline 53. [Internet]. National 608
Institute for Health and Clinical Excellence. 2007.
609
52. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A, et al. The Chronic 610
Fatigue Syndrome - a Comprehensive Approach to Its Definition and Study. Ann Intern Med.
611
1994;121(12):953-9. PubMed PMID: WOS:A1994PW08300009.
612
53. Brurberg KG, Fonhus MS, Larun L, Flottorp S, Malterud K. Case definitions for chronic 613
fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a systematic review. BMJ open.
614
2014;4(2):e003973. doi: 10.1136/bmjopen-2013-003973. PubMed PMID: 24508851; PubMed 615
Central PMCID: PMC3918975.
616
54. Nisenbaum R, Reyes M, Unger ER, Reeves WC. Factor analysis of symptoms among 617
subjects with unexplained chronic fatigue: what can we learn about chronic fatigue syndrome?
618
Journal of psychosomatic research. 2004;56(2):171-8. doi: 10.1016/S0022-3999(03)00039-4.
619
PubMed PMID: 15016574.
620
55. Sullivan PF, Pedersen NL, Jacks A, Evengard B. Chronic fatigue in a population sample:
621
definitions and heterogeneity. Psychological medicine. 2005;35(9):1337-48. doi:
622
10.1017/S0033291705005210. PubMed PMID: 16168156.
623
28 56. Wyller VB, Helland IB. Relationship between autonomic cardiovascular control, case 624
definition, clinical symptoms, and functional disability in adolescent chronic fatigue syndrome: an 625
exploratory study. BioPsychoSocial medicine. 2013;7(1):5. doi: 10.1186/1751-0759-7-5. PubMed 626
PMID: 23388153; PubMed Central PMCID: PMC3570350.
627
57. Chalder T, Berelowitz G, Pawlikowska T, Watts L, Wessely S, Wright D, et al. Development 628
of a fatigue scale. Journal of psychosomatic research. 1993;37(2):147-53. PubMed PMID: 8463991.
629
58. Tanaka M, Fukuda S, Mizuno K, Imai-Matsumura K, Jodoi T, Kawatani J, et al. Reliability 630
and validity of the Japanese version of the Chalder Fatigue Scale among youth in Japan. Psychol 631
Rep. 2008;103(3):682-90. doi: 10.2466/pr0.103.3.682-690. PubMed PMID: 19320199.
632
59. Sund AM, Larsson B, Wichstrom L. Depressive symptoms among young Norwegian 633
adolescents as measured by the Mood and Feelings Questionnaire (MFQ). European child &
634
adolescent psychiatry. 2001;10(4):222-9. PubMed PMID: 11794547.
635
60. Wechsler D. Wechsler Intelligence Scale for Children – Fourth edition (Norwegian version).
636
Stockholm, Sweden: The Psychological Corporation; 2004.
637
61. Nie H, Arendt-Nielsen L, Andersen H, Graven-Nielsen T. Temporal summation of pain 638
evoked by mechanical stimulation in deep and superficial tissue. J Pain. 2005;6(6):348-55. doi:
639
10.1016/j.jpain.2005.01.352. PubMed PMID: 15943956.
640
62. Grant PM, Ryan CG, Tigbe WW, Granat MH. The validation of a novel activity monitor in 641
the measurement of posture and motion during everyday activities. Br J Sports Med.
642
2006;40(12):992-7. doi: 10.1136/bjsm.2006.030262. PubMed PMID: 16980531; PubMed Central 643
PMCID: PMCPMC2577473.
644
63. Ryan CG, Grant PM, Tigbe WW, Granat MH. The validity and reliability of a novel activity 645
monitor as a measure of walking. Brit J Sport Med. 2006;40(9):779-84. doi:
646
10.1136/bjsm.2006.027276. PubMed PMID: WOS:000239998100009.
647
64. Dowd KP, Harrington DM, Donnelly AE. Criterion and Concurrent Validity of the activPAL 648
(TM) Professional Physical Activity Monitor in Adolescent Females. Plos One. 2012;7(10). doi:
649
ARTN e4763310.1371/journal.pone.0047633. PubMed PMID: WOS:000310050200036.
650
65. Dahlgren G, Carlsson D, Moorhead A, Hager-Ross C, McDonough SM. Test-retest reliability 651
of step counts with the ActivPAL (TM) device in common daily activities. Gait Posture.
652
2010;32(3):386-90. doi: 10.1016/j.gaitpost.2010.06.022. PubMed PMID: WOS:000283459100021.
653
66. Whitfield-Gabrieli S, Nieto-Castanon A. Conn: a functional connectivity toolbox for 654
correlated and anticorrelated brain networks. Brain Connect. 2012;2(3):125-41. doi:
655
10.1089/brain.2012.0073. PubMed PMID: 22642651.
656
67. Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE. Spurious but systematic 657
correlations in functional connectivity MRI networks arise from subject motion. Neuroimage.
658
2012;59(3):2142-54. doi: 10.1016/j.neuroimage.2011.10.018. PubMed PMID: 22019881; PubMed 659
Central PMCID: PMCPMC3254728.
660
68. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. An automated method for neuroanatomic 661
and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 2003;19(3):1233-9.
662
doi: Doi 10.1016/S1053-8119(03)00169-1. PubMed PMID: WOS:000184485400068.
663
69. Behzadi Y, Restom K, Liau J, Liu TT. A component based noise correction method 664
(CompCor) for BOLD and perfusion based fMRI. Neuroimage. 2007;37(1):90-101. doi:
665
10.1016/j.neuroimage.2007.04.042. PubMed PMID: 17560126; PubMed Central PMCID:
666
PMCPMC2214855.
667
70. Chai XJ, Castanon AN, Ongur D, Whitfield-Gabrieli S. Anticorrelations in resting state 668
networks without global signal regression. Neuroimage. 2012;59(2):1420-8. doi:
669
29 10.1016/j.neuroimage.2011.08.048. PubMed PMID: 21889994; PubMed Central PMCID:
670
PMCPMC3230748.
671
71. Jolles DD, van Buchem MA, Crone EA, Rombouts SA. A comprehensive study of whole-672
brain functional connectivity in children and young adults. Cereb Cortex. 2011;21(2):385-91. doi:
673
10.1093/cercor/bhq104. PubMed PMID: 20542991.
674
72. Collin SM, Nuevo R, van de Putte EM, Nijhof SL, Crawley E. Chronic fatigue syndrome (CFS) 675
or myalgic encephalomyelitis (ME) is different in children compared to in adults: a study of UK and 676
Dutch clinical cohorts. BMJ open. 2015;5(10):e008830. doi: 10.1136/bmjopen-2015-008830.
677
PubMed PMID: 26510728; PubMed Central PMCID: PMCPMC4636651.
678
73. Pannekoek JN, van der Werff SJ, Meens PH, van den Bulk BG, Jolles DD, Veer IM, et al.
679
Aberrant resting-state functional connectivity in limbic and salience networks in treatment--naive 680
clinically depressed adolescents. J Child Psychol Psychiatry. 2014;55(12):1317-27. doi:
681
10.1111/jcpp.12266. PubMed PMID: 24828372.
682
74. Wechsler D. Wechsler Abbreviated Scale of Intelligence (WASI). Norwegian manual 683
supplement. Stockholm, Sweden: Pearson; 2007.
684
75. Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H, et al. Dissociable 685
intrinsic connectivity networks for salience processing and executive control. J Neurosci.
686
2007;27(9):2349-56. doi: 10.1523/JNEUROSCI.5587-06.2007. PubMed PMID: 17329432; PubMed 687
Central PMCID: PMCPMC2680293.
688
76. Menon V. Large-scale brain networks and psychopathology: a unifying triple network 689
model. Trends Cogn Sci. 2011;15(10):483-506. doi: 10.1016/j.tics.2011.08.003. PubMed PMID:
690
21908230.
691
77. Zaki J, Davis JI, Ochsner KN. Overlapping activity in anterior insula during interoception 692
and emotional experience. Neuroimage. 2012;62(1):493-9. doi:
693
10.1016/j.neuroimage.2012.05.012. PubMed PMID: 22587900.
694
78. Khan NA, Hillman CH. The relation of childhood physical activity and aerobic fitness to 695
brain function and cognition: a review. Pediatr Exerc Sci. 2014;26(2):138-46. doi:
696
10.1123/pes.2013-0125. PubMed PMID: 24722921.
697
79. Kurniawan IT, Guitart-Masip M, Dayan P, Dolan RJ. Effort and valuation in the brain: the 698
effects of anticipation and execution. J Neurosci. 2013;33(14):6160-9. doi:
699
10.1523/JNEUROSCI.4777-12.2013. PubMed PMID: 23554497; PubMed Central PMCID:
700
PMCPMC3639311.
701
80. Padmala S, Pessoa L. Reward reduces conflict by enhancing attentional control and biasing 702
visual cortical processing. J Cogn Neurosci. 2011;23(11):3419-32. doi: 10.1162/jocn_a_00011.
703
PubMed PMID: 21452938; PubMed Central PMCID: PMCPMC3175266.
704
81. Miller, Jones JF, Drake DF, Tian H, Unger ER, Pagnoni G. Decreased basal ganglia activation 705
in subjects with chronic fatigue syndrome: association with symptoms of fatigue. Plos One.
706
2014;9(5):e98156. doi: 10.1371/journal.pone.0098156. PubMed PMID: 24858857; PubMed 707
Central PMCID: PMCPMC4032274.
708
82. Mizuno K, Tanaka M, Tanabe HC, Joudoi T, Kawatani J, Shigihara Y, et al. Less efficient and 709
costly processes of frontal cortex in childhood chronic fatigue syndrome. Neuroimage Clin.
710
2015;9:355-68. doi: 10.1016/j.nicl.2015.09.001. PubMed PMID: 26594619; PubMed Central PMCID:
711
PMCPMC4589845.
712
83. Mizuno K, Kawatani J, Tajima K, Sasaki AT, Yoneda T, Komi M, et al. Low putamen activity 713
associated with poor reward sensitivity in childhood chronic fatigue syndrome. NeuroImage:
714
Clinical. 2016;12:600-6. doi: http://dx.doi.org/10.1016/j.nicl.2016.09.016.
715
30 84. Kostovic I. Structural and histochemical reorganization of the human prefrontal cortex 716
during perinatal and postnatal life. Prog Brain Res. 1990;85:223-39; discussion 39-40. PubMed 717
PMID: 2094895.
718
85. Changeux JP, Danchin A. Selective stabilisation of developing synapses as a mechanism for 719
the specification of neuronal networks. Nature. 1976;264(5588):705-12. PubMed PMID: 189195.
720
86. Chechik G, Meilijson I, Ruppin E. Synaptic pruning in development: a computational 721
account. Neural Comput. 1998;10(7):1759-77. PubMed PMID: 9744896.
722
87. Goldman-Rakic PS. Development of cortical circuitry and cognitive function. Child Dev.
723
1987;58(3):601-22. PubMed PMID: 3608641.
724
88. Apkarian AV. Pain perception in relation to emotional learning. Curr Opin Neurobiol.
725
2008;18(4):464-8. doi: 10.1016/j.conb.2008.09.012. PubMed PMID: 18835354; PubMed Central 726
PMCID: PMCPMC2592605.
727
89. Apkarian AV, Baliki MN, Geha PY. Towards a theory of chronic pain. Progress in 728
neurobiology. 2009;87(2):81-97. doi: 10.1016/j.pneurobio.2008.09.018. PubMed PMID: 18952143;
729
PubMed Central PMCID: PMCPMC2650821.
730
90. Baliki MN, Geha PY, Apkarian AV. Parsing pain perception between nociceptive 731
representation and magnitude estimation. J Neurophysiol. 2009;101(2):875-87. doi:
732
10.1152/jn.91100.2008. PubMed PMID: 19073802; PubMed Central PMCID: PMCPMC3815214.
733
91. Lamm C, Meltzoff AN, Decety J. How do we empathize with someone who is not like us? A 734
functional magnetic resonance imaging study. J Cogn Neurosci. 2010;22(2):362-76. doi:
735
10.1162/jocn.2009.21186. PubMed PMID: 19199417.
736
92. Catani M, Thiebaut de Schotten M. A diffusion tensor imaging tractography atlas for 737
virtual in vivo dissections. Cortex. 2008;44(8):1105-32. doi: 10.1016/j.cortex.2008.05.004. PubMed 738
PMID: 18619589.
739
93. Zeineh MM, Kang J, Atlas SW, Raman MM, Reiss AL, Norris JL, et al. Right arcuate 740
fasciculus abnormality in chronic fatigue syndrome. Radiology. 2015;274(2):517-26. doi:
741
10.1148/radiol.14141079. PubMed PMID: 25353054.
742
94. Kawatani J, Mizuno K, Shiraishi S, Takao M, Joudoi T, Fukuda S, et al. Cognitive dysfunction 743
and mental fatigue in childhood chronic fatigue syndrome--a 6-month follow-up study. Brain &
744
development. 2011;33(10):832-41. doi: 10.1016/j.braindev.2010.12.009. PubMed PMID:
745
21530119.
746
95. Castell BD, Kazantzis N, Moss-Morris RE. Cognitive Behavioral Therapy and Graded 747
Exercise for Chronic Fatigue Syndrome: A Meta-Analysis. Clin Psychol-Sci Pr. 2011;18(4):311-24.
748
doi: 10.1111/j.1468-2850.2011.01262.x. PubMed PMID: WOS:000298355100004.
749
96. White PD, Goldsmith KA, Johnson AL, Potts L, Walwyn R, DeCesare JC, et al. Comparison of 750
adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist 751
medical care for chronic fatigue syndrome (PACE): a randomised trial. Lancet.
752
2011;377(9768):823-36. doi: 10.1016/S0140-6736(11)60096-2. PubMed PMID: 21334061; PubMed 753
Central PMCID: PMCPMC3065633.
754
97. Nijhof SL, Bleijenberg G, Uiterwaal CSPM, Kimpen JLL, van de Putte EM. Effectiveness of 755
internet-based cognitive behavioural treatment for adolescents with chronic fatigue syndrome 756
(FITNET): a randomised controlled trial. Lancet. 2012;379(9824):1412-8. doi: Doi 10.1016/S0140-757
6736(12)60025-7. PubMed PMID: WOS:000302806800029.
758
98. Gordon BA, Knapman LM, Lubitz L. Graduated exercise training and progressive resistance 759
training in adolescents with chronic fatigue syndrome: a randomized controlled pilot study. Clin 760
Rehabil. 2010;24(12):1072-9. doi: 10.1177/0269215510371429. PubMed PMID: 20605858.
761
31 99. Ansell EB, Rando K, Tuit K, Guarnaccia J, Sinha R. Cumulative adversity and smaller gray 762
matter volume in medial prefrontal, anterior cingulate, and insula regions. Biol Psychiatry.
763
2012;72(1):57-64. doi: 10.1016/j.biopsych.2011.11.022. PubMed PMID: 22218286; PubMed 764
Central PMCID: PMCPMC3391585.
765
100. Pani L, Porcella A, Gessa GL. The role of stress in the pathophysiology of the dopaminergic 766
system. Molecular psychiatry. 2000;5(1):14-21. PubMed PMID: 10673764.
767
101. Botvinick M, Braver T. Motivation and cognitive control: from behavior to neural 768
mechanism. Annu Rev Psychol. 2015;66:83-113. doi: 10.1146/annurev-psych-010814-015044.
769
PubMed PMID: 25251491.
770
102. Burkey AR, Carstens E, Jasmin L. Dopamine reuptake inhibition in the rostral agranular 771
insular cortex produces antinociception. J Neurosci. 1999;19(10):4169-79. PubMed PMID:
772
10234044.
773
103. Ohara PT, Granato A, Moallem TM, Wang BR, Tillet Y, Jasmin L. Dopaminergic input to 774
GABAergic neurons in the rostral agranular insular cortex of the rat. J Neurocytol. 2003;32(2):131-775
41. PubMed PMID: 14707548.
776
104. Lou HC, Rosenstand A, Brooks DJ, Bender D, Jakobsen S, Blicher JU, et al. Exogenous 777
dopamine reduces GABA receptor availability in the human brain. Brain Behav. 2016;6(7):e00484.
778
doi: 10.1002/brb3.484. PubMed PMID: 27247854; PubMed Central PMCID: PMCPMC4864053.
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