Eggstokkreft 520 (66 år) 49%
Livmorkropp 702 (68 år) 84%
Livmorhals 316 (45 år) 81%
Andre 139
Totalt 1677
Alle tilfeller kvinner 15443
Bryst 3589
Kreftregisteret 2017
GYNEKOLOGISK KREFT I NORGE
Endometrial cancer
• The most common gynecological cancer in industrialised countries
• > 90 % of cases in women > 50 years
• 80 % of cases diagnosed in stage I
Endometrial hyperplasia
Type Premalignant
potential (% cancer)
Simple < 5%
Komplex without atypia
5 – 15%
Komplex with atypia ~ 30%
Postmenopausal bleeding - etiology
Factor % forekomst
Østrogen behandling
30
Atrofisk endometritt/vaginitt
30
Endometrie cancer
15
Endometrie hyperplasi
5
Endometrie/cervix polypp
10
Diverse (cx.cancer, uterussarkom,
urinveier, traume)
10
Cancer corp. uteri - pathology
• Endometroid adenocarcinoma (80%)
• Serous papillary carcinoma (5-10%)
• Clear cell carcinoma (3-5%)
• Carcinosarcoma (3-4 %)
• Mucinous carcinoma (< 3%)
• Squamous cell carcinoma (<1%)
• Leiomyosarcoma (58%)
• Endometrial stroma sarcoma (32%)
93%
7%
Endometriecancer
Risikogrupper
Lymphadenectomy in endometrial cancer
PRO
• Proper staging
according to FIGO
• Prognostication
• Triage for further therapy after surgery
• Potential therapeutic effect of
lymphadenectomy
CON
• Increased risk of per- and post-operative complications
• Time- and money-
consuming procedure
• Therapeutic effect undocumented
3
1 8
Benedetti Panici 2008 Kitchener 2009
May 2010
6
Injection of dye into the cervix at 9 and 3 o’clock
9
HE, 20 X CKAE1/AE3, 20 X
12
Hereditary endometrial cancer
•
HNPCC carriers + site specific form (?)•
5-8% of all endometrial cancer•
~ 50% life time risk for HNPCC carriers,2nd. most frequent HNPCC cancer form
Aarnio et al. Int J Cancer 1999
