Surface modification of liposomes increases drug efficacy in local vaginal therapy

Liposomal preparations (empty liposomes or liposomes containing chloramphenocol) were incorporated in prepared chitosan hydrogels (concentration varying from 1 to 6%, w/w) by

38 Figure 16: Detachment force of three different hydrogels applied to vaginal tissue (containing 2.5 % chitosan as a final concentration.. 39 Figure 17: Amount of hydrogel

A liposomal zeta potential close to neutral would be favorable considering the release of liposomally-associated molecules when liposomes are incorporated in chitosan hydrogel, as

The vesicle size before and after coating, entrapment effi- ciencies for model drug atenolol, and the mucoadhesive strength of the delivery systems based on chitosan, Car- bopol,

Beneficial effects of bioadhesive coating for curcumin pharmacokinetic behavior are in line with publications on drug delivery systems containing the same polymers –

As a result of their properties, liposomes have already been used as drug delivery systems in treatment and prevention of vaginal viral infections and cervical cancer, though the

potential of each proposed nanodelivery systems with respect to topical vaginal drug delivery, 16.. considering the uses of nanodelivery systems in other routes of drug

The resulting chitosan-containing liposomes were characterized for their size distribution, zeta potential, entrapment efficiency and in vitro release of a drug