SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1

Consistent with previous reports (3, 4, 14), IRF1 levels in uninfected MDMs were low and both IRF1 mRNA and protein expression were induced by HMPV infection.. Induction of IRF1

The marker of oxidative stress (4-HNE) as well as autophagy markers Beclin-1 and p62/SQSTM1 and protein aggregation marker ubiquitin were sig- ni fi cantly elevated in NRF-2 KO

In fibroblast cell cultures IL-33 was induced by tumor necrosis factor- (TNF ) and IL-1 , but we found that the TLR3 agonist poly (I:C) induced even higher expression levels,

The analysis of gene expression assessed by RT-qPCR showed a significantly increase of cell-surface markers cd80/86, mhcii and cd83 in splenocytes induced with Ss rIFNg for 15

In this study, we have shown that TAK1 controls the activities of p62, transitioning it away from functioning as a selective autophagy receptor and instead

In both cell lines, we found that PRL-3 induced expression of genes belonging to the type 1 interferon (IFN-I) signaling pathway, and activation of STAT1 and STAT2.. This activation

By utilizing reporter expression of a marker insertion near the wild type allele of nrf1 combined with transgenic rescue, I show that a single heat shock induced pulse of

The present study showed that BMSC-CM induced higher secretion of PGE 2, IL-10, IL-8, and IL-6, and RANTES in hDPC in vitro and attenuated the gene expression of IL-1 b , IL-6 and