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Annual Report
Research Activity 2019
Division of Orthopaedic Surgery
University of Oslo, Diakonhjemmet Hospital
and Oslo University Hospital
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Content
Research activity at the Division of Orthopaedic Surgery and Department of Rheumatology,
Diakonhjemmet Hospital ... 2 Osteoarthritis Research Group ... 4 Group Leader: Lars Nordsletten
Pediatric Orthopaedics ... 6 Group Leader: Joachim Horn
Biomechanics Laboratory ... 9 Group Leader: Harald Steen
Center for Implant and Radiostereometric Research Oslo – CIRRO ... 14 Group Leaders: Stephan Röhrl and Lars Nordsletten
Hand ... 19 Group Leader: Magne Røkkum
Norwegian research center for Active Rehabilitation – NAR ... 22 Group Leader: May Arna Risberg
Oncological Orthopedics ... 25 Group Leader: Olga Zaikova
Orthopaedic traumatology ... 28 Group Leader: Jan Erik Madsen
Oslo Sports Trauma Research Center - OSTRC ... 31 Group Leaders: Lars Engebretsen and Roald Bahr
Research group SPINE ... 35 Group Leader: Christian Hellum
Research in rheumatological diseases – Diakonhjemmet Hospital ... 39 Group Leader: Tore Kvien
Publication list OPK research groups 2019 ... 41 Publication list Department of Rheumatology, Diakonhjemmet Hospital 2019 ... 55
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Oslo University Hospital and the University of Oslo
Oslo University Hospital (OUH) is Norway’s largest hospital with over 24 000 employees and a budget of 23 billion NOK. The Hospital has a local function for parts of Oslo's population. It has a regional function for the inhabitants in the South-Eastern Norway Regional Health Authority, and it also has a large number of national functions. The Hospital is responsible for the majority of medical research and education of health personnel in Norway.
The University of Oslo (UiO) is Norway's largest research and educational institution with 28 000 students and 7000 employees. Professional breadth and internationally recognized research environments make UiO an important contributor to society. The Faculty of Medicine was established in 1814 and works for progressive education, research and dissemination for the patients’ and society’s best interests.
From Division Director Rolf Riise
Being the largest hospital in Norway, Oslo University Hospital provides highly specialized health care services to the citizens of Oslo and the South-East Health Region. In addition, the Hospital has a nationwide responsibility for a number of national and multi-regional assignments. The Division of Orthopaedics is one of twelve medical divisions. It encompasses the fields of orthopedic traumatology, hand surgery including retransplant surgery, prosthetic surgery, oncology surgery, spinal surgery, scoliosis surgery, pediatric surgery and arthroscopic surgery. The research activity of Department of Rheumatology, Diakonhjemmet Hospital is organizationally linked to Division of Orthopedics.
The proximity to patients and their medical issues are the cornerstones for the research conducted at our Division, which is aimed at improving patient care. High ethical standards ensure the confidentiality, and our goal is to continuously improve diagnostics, treatment and management for all our patients.
Research activity at the Division of Orthopaedic Surgery and Department of Rheumatology, Diakonhjemmet
Hospital
The Division of Orthopedic’s research activity is organized into 11 different research groups covering a broad range of basic and clinical research with an overall aim to improve patient care with emphasis on diagnostic, therapeutic and preventive measures. Most group leaders have a combined position at Oslo University Hospital and the University of Oslo. In total the Division has 11 Professors, 2 Associate Professors, postdoctoral fellowships, several PhD students and administrative and technical staff.
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The Division has an Advisory Research Board which in 2019 consisted of: Professor Lars Nordsletten, Professor Olav Røise, Professor Jan Erik Madsen, Professor Lars Engebretsen, Professor Harald Steen, Professor Inger Holm, Professor May Arna Risberg, Professor Ivan Hvid, Finance Manager Anne-Grethe Akselsen, Division Director Rolf Riise, Consultant Olga Zaikova, Patient Representative and User Inger Ljøstad and Reseach Nurse and Assistant Administrative Manager Kari Anne Hakestad. In 2019 there were in total 99 registered peer reviewed publications and 9 PhD dissertations.
Diakonhjemmet Hospital is a private, non-profit hospital with defined responsibilities for the health care system both in Oslo, in the health region as well as nationally. Department of Rheumatology has responsibility for people with rheumatic joint diseases living in the entire area of Oslo and a regional function for the inhabitants in the South-Eastern Norway Regional Health Authority. Two national highly specialized functions are located at the Hospital: The Norwegian National Unit for Rehabilitation for Rheumatic Patients with Special Needs and the Norwegian National Advisory Unit on Rehabilitation in Rheumatology. The Department has since 2008 held the position as EULAR Center of Excellence and has in addition to patient care a strong focus on clinical and epidemiological research, education and information to patients and their relatives. Two professors; professor Tore Kristian Kvien and professor Tillmann Uhlig have combined positions in the Department of Rheumatology and University of Oslo. The Department has an extensive research production, and there were in total 54 registered peer reviewed publications and 3 PhD dissertations in 2019.
Olav Røise
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Osteoarthritis Research Group
Group Leader
Lars Nordsletten, Prof, Division of Orthopaedics, UiO ([email protected]) / Head of R & D, Division of Orthopaedic Surgery, OUH ([email protected])
Research profile and aims
To study the etiologi, treatment, and prevention of osteoarthritis (OA). We are primarily studying knee, hip and hand OA.
Ongoing projects
∙ Training in knee OA: RCT between different training forms
∙ Risk factors for OA in hip, knee and hand: HUNT-NLR-OUH study and Ullensaker study
∙ Development of hand OA
∙ AktivA: implementation of treatment and prevention and registry of OA in primary care in Norway
∙ MRI changes with hand OA: Trapezium MRI findings compared to histology
∙ OMEX: RCT between traing and operation in meniscal injury
Group Members
∙ May Arna Risberg, Prof
∙ Tore K. Kvien, Prof
∙ Till Uhlig, Prof
∙ Kåre Birger Hagen, Prof
∙ Ida K. Haugen, Post doc
∙ Gunnar Flugsrud, Senior Consultant
∙ Alf Inge Hellevik, PHD fellow
∙ Kristin Bølstad, Research coordinator
∙ Nina Østerås, Post doc
∙ Karin Magnusson, Post doc
∙ Alexander Mathiessen, PhD fellow
∙ Britt Elin Øyestad, Post doc
∙ Nina J. Kise, PhD fellow
∙ Marianne Bakke Johnsen, Post doc
∙ Eirik Weldingh, Phd fellow
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Most important national and international collaborators
Scientific production of the research group in 2019
Peer reviewed original research articles: 36
PhD:
Nina Jullum Kise: “Treatment of Degenerative Meniscal Tears in Middle-Aged Patiens”
Selected publications:
Lie, M. M., M. A. Risberg, K. Storheim, L. Engebretsen and B. E. Oiestad (2019).
"What's the rate of knee osteoarthritis 10 years after anterior cruciate ligament injury? An updated systematic review"
Br J Sports Med 53(18): 1162-1167
Magnusson, K., A. Turkiewicz, S. Timpka and M. Englund (2019).
"A Prediction Model for the 40-Year Risk of Knee Osteoarthritis in Adolescent Men"
Arthritis Care Res (Hoboken) 71(4): 558-562
Weldingh, E., M. B. Johnsen, K. B. Hagen, N. Osteras, M. A. Risberg, B. Natvig, B. Slatkowsky-Christensen, A. M.
Fenstad, O. Furnes, L. Nordsletten and K. Magnusson (2019)
"The Maternal and Paternal Effects on Clinically and Surgically Defined Osteoarthritis"
Arthritis Rheumatol 71(11): 1844-1848
National International
‐ The Norwegian Arthroplasty Register
‐ The Norwegian Cruciate Ligament Register
‐ The Norwegian Hip Fracture Register
‐ NTNU, HUNT Research Center
‐ David T. Felson, Boston University, USA
‐ Martin Englund, Lund University, Sweden
‐ Lynn Snyder-Mackler, University of Delaware, USA
Funding
‐ South-Eastern Norway Regional Health Authority
‐ Norwegian Extra Foundation for Health and Rehabilitation
‐ The Research Council of Norway
‐ Foundation of Sophies Minde
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Pediatric Orthopaedics
Group Leader
Joachim Horn, Associate Professor, Section of Children’s Orthopaedics and Reconstructive Surgery, UiO ([email protected]) /OUH ([email protected])
Research profile and aims
The main intention of the group is to promote clinical and experimental research within the field of children’s orthopaedics and reconstructive surgery. Core areas of research are: limb deformity (limb lengthening and growth modulation) and children’s hip (Perthes, DDH and SCFE). Novel areas of research are: mixed reality/holographic technology within the field of orthopaedics and research concerning patient safety in children’s orthopaedics.
Ongoing projects
1. Limb lengthening and reconstruction (Joachim Horn)
“Growth modulation in correction of leg length and axial deviations”; PhD project, Anne Berg Breen
“The timing of percutaneous epiphysiodesis for leg length discrapency – an evaluation of four different prediction methods”
“Analysis of growth during temporary epiphysiodesis and hemiepiphysiodesis – a radiostereometric analysis”
“Temporary hemiepiphysiodesis with a tenson-plate – a follow-up to maturity”
“Correlation of skeletal age based on three different evaluation methods” (Greulich and Pyle, Sauvegrain and BoneXpert)
Group Members
∙ Terje Terjesen, Professor emeritus, UiO
∙ Ivan Hvid, Professor emeritus, UiO
∙ Harald Steen, MD/PhD, OUH
∙ Ola Wiig, MD/PhD, OUH
∙ Stefan Huhnstock, MD/PhD, OUH
∙ Anders Wensaas, MD/PhD, OUH
∙ Anne Berg Breen, MD, PhD-candidate, OUH
∙ Anders Grønseth, MD, PhD-candidate, OUH
∙ Andreas Knaus, MD, OUH
∙ Vera Halvorsen, MD, OUH
∙ Patrick Bjørge, PT, MSc-cand, OUH
∙ Johan Brevik, PT
∙ Anne Marthe Svendsen Rysst-Heilmann, PT
∙ Lærke Lindskov, Certified prosthetist & orthotist (CPO), Clinical Gait Analyst
∙ Sanyalak Niratiairak, PhD, Head engineer, UiO
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“Idiopathic increased femoral anteversjon”; PhD project Anders Grønseth
“Derotational osteotomy in the femur with either percutaneous osteotomy and intrameduallry nailing or with an open approach and plating – a randomized controlled trial”
“Three-dimensional gait analysis before and after derotational osteotomy in patienys with idiopathic increased femoral anteversion”
“Long-term follow-up of untreated patients with increased femoral anteversion”
“Femoral lengthening might impair physical function and lead to joint cartilage degeneration in adjacent joints – a study of 10 patients with 27 to 34 years follow-up”, MSc-project, Patrick Bjørge
“Knee stability in achondroplasia after tibial lengthening with concurrent distalisation of the fibular head”
2. Children’s hip
“A nationwide Perthes study – a long term follow-up with more than 20 years” (Stefan Huhnstock)
“The prognostic value of the head-shaft angle in children with cerebral palsy” (Terje Terjesen)
“Prognostic value of severity of dislocation in late-detected developmental dysplasia of the hip” (Terje Terjesen)
“Management of late-detected DDH in children under three years of age” (Terje Terjesen) 3. Mixed Reality, Holographic technology (Ola Wiig)
“OrthoNav-mixed reality/holographic technology in orthopaedic surgery”, PhD project Inger Gruenbeck, MSc, Interventioncentre, OUH
4. Children’s foot and ankle
“Idiopathic toewalkers: a clinical intervention study for children from 7-14 years” (Lærke Lindskov and Andreas Knaus)
5. Skeletal dysplasia
Establishment of a “Norwegian Skeletal Dysplasia Register” in collaboration with the Norwegian National Advisory Unit on Rare Diseases, Department of Medical Genetics and Pediatric Endocrinology.
The register will be a base for broad interdisciplinary research within this field. (Joachim Horn) 6. Patient safety
“Characteristics of malpractice claims in pediatric orthopedics in Norway between 2012 – 2018”
(Joachim Horn) 7. Radiology
“Bone age evaluation by carpal MRI” (Ivan Hvid)
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Most important national and international collaborators
National International
‐ Lena Lande Wekre,MD, PhD, Norwegian National Advisory Unit on Rare Diseases
‐ Cecilie Rustad, MD, Department of Medical Genetics, OUH
‐ Cathrine Alsaker Heier, Divison of Pediatrics, Endocrinology
‐ The Intervention Centre, OUH
‐ Ida Rashida Khan Bukholm, MD, Professor, Norwegian University of Life Science, The Norwegian System of Patient Injury Compensation
‐ Ralph Sakkers, MD, PhD; EPOS Study Group Genetics and Metabolic Diseases
‐International Perthes Study Group
‐University of Graz, Austria (MR Bone Age)
Scientific production of the research group in 2019
Completed PhD’s
Stefan Huhnstock; “Radiographic assessment in Perthes disease”
Anders Wensaas; “Slipped capital femoral epiphysis, long-term outcome and the role of preoperative magnetic resonance imaging”
Peer reviewed original research articles: 5
Selected publications:
Terjesen T.
“Femoral and pelvic osteotomies for severe hip displacement in nonambulatory children with cerebral palsy: a prospective population-based study of 31 patients with 7 years' follow-up”
Acta Orthop. 2019 Dec;90(6):614-621 Terjesen T. CORR Insights®
“What Is the Prevalence of Cam Deformity After Prophylactic Pinning of the Contralateral Asymptomatic Hip in Unilateral Slipped Capital Femoral Epiphysis? A 10-year Minimum Follow up Study”
Clin Orthop Relat Res. 2019 May;477(5):1123-1125 Horn J, Hvid I, Huhnstock S, Breen AB, Steen H.
“Limb lengthening and deformity correction with externally controlled motorized intramedullary nails:
evaluation of 50 consecutive lengthenings”
Acta Orthop. 2019 Feb;90(1):81-87
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Funding
‐ Sophies Minde AS (Stefan Huhnstock)
‐ Innovation funds 2019 (Ola Wiig)
‐ Bergesenstiftelsen (Ola Wiig)
‐ Sophies Minde AS (Patrick Bjørge, Joachim Horn)
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Biomechanics Laboratory
Group Leader
Harald Steen, MD/DMSci, Head of Biomechanics Laboratory/Orthopaedic Consultant, Orthopedic Division, OUH, Rikshopitalet ([email protected]) / Professor emeritus, OsloMet ([email protected])
Research profile and aims
Biomechanics lab at the Department for Research and Development, Oslo University Hospital Orthopaedic Clinic, functions as a service-unit and contributes as a facilitator/catalysator for accomplishment of various research projects within the orthopaedic community in the Oslo region. The laboratory was established back in the 1960’ies as a common project between Sophies Minde National Orthopaedic Hospital and University of Oslo with 2 full time employees: One orthopaedic surgeon paid by the Hospital and one Engineer paid by the University.
The laboratory has previously organized the meetings of the ‘Biomechanics Forum’ 2-3 times a year during the periods 1996-2002 and 2013-2017, with a total of 31 meetings. Biomechanics Forum was a multidisciplinary discussion group of professionals and students. At present the plan is to establish a new national forum called the Norwegian Biomechanics Society (NSB) consistent with similar existing societies in Denmark and Sweden, and with a future expectation of making a common Scandinavian Bioemechanics Society.
Group members
∙ Sanyalak Niratisairak, PhD, UiO (Head engineer)
∙ Jan Egil Brattgjerd, MD/PhD-cand, OUH
∙ Knut Strømsøe, MD/DMSci, prof em UiO/Alumni
∙ Jan Rune Nilssen, Eng, Norwegian Defence Research Insititute (FFI)
∙ Bryan Wright, MD/PhD-cand, Ringerike Hospital
∙ Ingrid Skaaret, CPO/MSc/PhD-cand, Sophies Minde Ortopedi AS (SMO)
∙ Jette Schack, PT/MSc/PhD-cand, OUH, SMO, OsloMet
∙ Anne Berg Breen, MD/PhD-cand, OUH
∙ Pavel Mukherjee, MD, Sørlandet Hospital, Kristiansand
∙ Øyvind Grimsrud, PT/MSc, OUH
∙ Patrick Aleksander Bjørge, PT/MSc-cand, OUH
Associate group members
∙ Jens Ivar Brox, MD/DMSci, OUH, prof UiO
∙ Are Hugo Pripp, MSc/PhD, OUH, prof OsloMet
∙ Ivan Hvid, MD/DMSci, OUH, prof em UiO
∙ Ragnhild Gunderson, MD, OUH
∙ Joachim Horn, MD/PhD, OUH
∙ Jens Bojsen-Møller, MD/PhD, prof Oslo University College of Sports (OUCS)
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The laboratory is furnished with technological equipment for mechanical and functional testing, and participates in planning, execution, analyses, and publishing of clinical and experimental studies.
Biomechanics lab was granted 1.37 mill NOK from the Hospital’s Investment budget 2019 for upgrading of our mechanical testing machine (MTS, MiniBionix 858), located at the Institute for Surgical Research.
The new equipment will be a high-speed digital image video camera with integrated 3D motion analysis for detailed documentation of the deformation process within the test object during mechanical testing.
The procurement process started in September 2019.
In daily clinical activity the Biomechanics lab has been part of the Paediatric Orthopaedics and Reconstructive Surgery Section at Rikshospitalet, mainly contributing with preoperative assessment of patients with limb length discrepancy and other deformities, and monitoring of patients operated with distraction osteogenesis/callotasis by use of intramedullary nails or external fixators.
Ongoing projects
∙ Biomechanics of locking plates in femoral neck fixation (JEB/PhD Thesis in progress)
∙ Biomechanical studies of bone fixation (BW/PhD Thesis in progress)
∙ Assessment of Mobility and Prefrontal Cortical Activity by use of functional Near-Infrared Spectroscopy (fNIRS) in Persons with Lower Limb Amputation (JS/PhD Thesis in progress)
∙ Children with cerebral palsy- the impact of ankle-foot orthoses on gait function after lower limb surgery (IS/PhD Thesis in progress)
∙ Planning and treatment of epiphysiodesis - Outcome of various methods (ABB/PhD Thesis in progress)
∙ Comparison of various methods for bone age assessment
∙ Radiostereometric (RSA) Growth-Analyses after (Hemi-)Epiphysiodeses
∙ Predictors for long-term curve progression after Boston brace treatment of idiopathic scoliosis
∙ Forces, Load-share and Strain in Ankle Arthrodiatasis
∙ Contribution of Soft and Hard Tissue Resistance during Limb Lengthening Procedures
∙ The Birch Classification for Congenital Fibular Deficiency Can Predict Treatment Modality and Clinical Outcome in Young Adults Born With Lower-Limb Deficiencies
∙ Forces, Load-Share and Strain during the Callotasis Process
∙ Radionstereometric (RSA) Monitoring in Orthopaedic Reconstructive Surgery
∙ The Influence of an Intact or Healed Osteotomized Fibula on the Measured Load-Share Value after a Tibial Lengthening Osteotomy - A Cadaver Pilot Study
∙ Bone Age Assessment by use of MRI and Ultrasound
∙ Radiostereometric (RSA) Monitoring in Orthopaedic Reconstructive Surgery
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Most important national and international collaborators
National International
‐ Jan Rune Nilssen, Norwegian Defence Research Establishment, Kjeller:
Mechanical testing projects
‐ Geir Hjorthaug, MD, MaHaHo:
Experimental bone healing studies
‐ Bryan Wright, MD, Ringerike Hospital:
Mechanical properties and bone mineral parameters Per-trochanteric Femoral Fractures
‐ Pavel Mukherjee, MD, Harstad Hospital:
Sub-trochanteric Femoral Fractures
‐ William MacKenzie, MD and Tariq Rahman, PhD, Neumors, Alfred I. duPont Hospital for Children, Wilmington, Delaware, USA:
Experimental limb lengthening project
‐ Søren Kold, MD/PhD and Markus Winther Frost, Aalborg University Hospital, Denmark:
Experimental limb lengthening project
‐ Martin Urschler, PhP and Darko Stern, MSc Ludwig Boltzmann Gesellschaft GmbH, Austria, Medical University of Graz, Austria:
Radiationless Bone Age assessment by MRI
‐ Stephen Grigg, PhD and Rhys Pullin, PhD, Cardiff School of Engineering, Cardiff University, UK
Acoustic Emission Project
Scientific production of the research group in 2019
Peer-Reviewed Publications (original research articles): 6
Selected publications:
Horn J, Huhnstock S, Breen AB, Hvid I, Steen H:
“Limb lengthening and deformity correction with externally controlled motorized intramedullary nails.
Evaluation of 50 consecutive lengthenings”
Acta Orthop, 2019 Feb;90(1):81-87.
Skaaret I, Steen H, Huse AB, Holm I:
“Comparison of gait with and without ankle-foot orthoses after lower-limb surgery in children with unilateral cerebral palsy”
J Child Orthop, 2019 Apr 1;13(2): 180-189
Schack J, Mirtaheri P, Steen H, Gjøvaag T:
“Assessing mobility for persons with Lower Limb Amputation: The Figure-of-8-Walk-Test with the inclusion of two novel Conditions”
Disabil Rehabil. 2019 Sep 17:1-10. doi: 10.1080/09638288.2019.1662495. [Epub ahead of print] PMID:
31526078
Published Abstracts
Horn J, Huhnstock S, Breen AB, Hvid I, Steen H:
“Limb lengthening and deformity correction with externally controlled motorized intramedullary nails.
Evaluation of 50 consecutive lengthenings”
European Paediatric Orthopaedic Society (EPOS), Tel Aviv, Israel , April 3-6, 2019, E-poster EP-071 J Child Orthop; 13 (Suppl 1): S 97, 2019
13 Papers Presented at Scientific Meetings
Schack J, Mirtaheri P, Steen H, Gjøvaag T:
“Prefrontal Cortical Activation during Challenging Walking Situations in Persons with Lower Limb Amputation – An fNIRS observational study. Preliminary Results.”
Best Paper Prize, Winner 2019, ISPO 17th World Congress, Kobe, Japan October 5-8, 2019
Hvid I, Horn J, Huhnstock S, Steen H, Breen AB, Bjørge P, Grimsrud Ø:
“Limb lengthening in children with achondroplasia”
International Skeletal Dysplasia Society (ISDS), 14th biennal meeting, Oslo Sep 11-14, 2019
Breen AB, Knaus A, Huhnstock S, Steen H, Hvid I, Horn J:
“Temporary hemiepiphysiodesis in the treatment of axial deviations around the knee and ankle in multiple osteochondromas”
4th Combined Congress of the ASAMI-Br & LLRS societies, Liverpool, UK August 27-30, 2019 Huhnstock S, Mertens J, Steen H, Horn J:
“Reconstructive surgery after partial trauma of the physis – 16 years’ experience by use of the Taylor Spatial Frame”
Norwegian Orthopaedic Association, Annual Scientific Meeting, Oslo, October 23-25, 2019.
Høstmøteboken, abstract #207, p. 105
Wright B, Grigg S, Brattgjerd JE, Steen H, Pullin R:
“Real time monitoring of screw insertion using acoustic emission can predict screw stripping in human cancellous bone”
Norwegian Orthopaedic Association, Annual Scientific Meeting, Oslo, October 23-25, 2019.
Høstmøteboken, abstract #608, p. 182
Markus Frost, Tariq Rahman , William Mackenzie, Harald Steen, Søren Kold:
“Continuous wireless force measurement in gradual and acute bone lengthening”
Danish Orthopaedic Federation (DOS) annual meeting, Vingsted Hotel and Konferenscenter, Vejle, Oct 23-25, 2019, Abstract #152, p.196
Grigg S, Wright BJ, Pullin R:
“A comparison of Acoustic Emission in Cadaveric Specimens and Artificial Sawbones during Surgical Screw Implants”
World Conference on Acoustic Emission (WCAE), Nov 5-8 2019, Guangzhou, China Papers in professional society journals
Horn J:
“Beinforlengelse og korreksjon av feilstilling med en ekstern kontrollerbar motorisert margnagle”
Ortopediskt Magasin, Sverige, nr 2; 54-55, 2019
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Center for Implant and Radiostereometric Research Oslo – CIRRO
Group Leaders
Stephan M. Röhrl, Ass. Prof., ([email protected])
Division of Orthopaedic Surgery, OUH, Head of the Norwegian Society for Hip and Knee Surgery, Board member of the Norwegian arthroplasty Registry
Lars Nordsletten, Prof., Dept of Orthopaedics, UiO
([email protected]) / Head of the research and development unit of the Divison of Orthopaedic Surgery, OUH ([email protected])
Group Members
Senior members:
∙ Finnur Snorrason, MD/PhD, OUH
∙ Vera Halvorsen, MD, OUH
∙ Marianne Westberg MDT/PhD, OUH
∙ Harald Steen, Professor, OUH
∙ Ragnhild Gundersen, MD radiolog, OUH Alumni (PhD):
∙ Wender Figwed, MD/PhD Bærum Hospital
∙ Berte Bøe, MD/PhD, OUH
∙ Einar Lindalen, MD/PhD Lovisenberg Hospital
∙ Jon Dahl, MD/PhD, OUH
∙ Thomas Kibsgård, MD/PhD, UiO and OUH
∙ Bernhard Flatøy, MD/PhD, OUH
∙ Eirik Aunan, MD, Lillehammer hospital
∙ Justin van Leeuwen, MD, Betanien Hospital
∙ Gunnar Petursson, MD, Lovisenberg Hospital PhD candidates:
∙ Trygve Glad, MD, OUH, LIS
∙ Alexander Fraser, MD, OUH, LIS
∙ Are Stødle, MD, OUH, LIS
∙ Jan Egil Brattgjerd, MD, OUH, LIS
∙ Frank David Ørn, MD, Kristiansund Hospital
∙ Carl Erik Alm, MD, OUH, LIS
∙ Ole-Christian Brun, MD, OUH
∙ Vinjar Hansen Myklevold, MD, OUH
∙ Peder Thoen, MD, Lovisenberg
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Research profile and aims
The overall aim of CIRRO is to perform sophisticated basic and clinical research in the field of orthopaedic surgery, material science and bone turnover, establish a team of dedicated researchers and collaborate nationally and internationally. Our intention is:
∙ To use and develop precise measurement methods in musculoskeletal research
∙ To study new treatment options (implants, surgical techniques, biotechnology, rehabilitation interventions and pharmacological treatment) and to ensure safe treatment to patients
∙ To study disease development (cartilage wear, bone loss, changes in body composition) together with other methods, in order to gain insight into mechanisms for disease and eventual treatment.
∙ To further develop CIRRO as a main research centre delivering sophisticated services to researchers in South-Eastern Norway Regional Health Authority and adjoint hopitals nationally.
2019
All our radigraphers are performing dynamic RSA-examinations with the Adore systems.
We have continued to recruit patients for our ongoing studies and have followed the patients clinically with CT and RSA. Researchers from all involved cities in Norway, Sweden and Japan met for a kick off meeting in Kyoto for our International multicenter study on spinal deformities. A homepage as a collaboration platform is established (https://intraks.org). All data will be collected in TSD.
Group Members (continued)
Radiographers:
∙ Alexis Hinohosa, CT and MRI radiographer, OUH
∙ Mona Risdal, CT radiographer, Application specialist CT, OUH
∙ Silje Klausen, BSC radiography, PgCert Reporting Radiography, OUH
∙ Kathrine Lamark, BSC radiography, MSC Diagnostic imaging, OUH Research coordinators:
∙ Marte Traae Magnusson, PT, Master, OUH
∙ Anne Christine Brekke, Head nurse, Master, OUH
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Researchers participated in the 6th biannual RSA congress in Aarhus, Denmark. CIRRO was selected as the organizer for the next international RSA congress in 2021. We reached out to sponsors (http://radiostereometry.org/2019/11/sponsor-invitation/).
The topic of the congress will be: “Imaging technology for safe implants and surgery for our patients”. We are currently in the planning phase of the congress.
Stephan Röhrl attended the first user meeting for a CT-based method for analyzing motion in implants.
This presents an interesting new technology that will face stringent verification and opens up for many new studies.
CIRRO arranged two meetings for the PhD-candicates, radiographers and coordinators. Several members of the group attended the annual research seminar at Kleivstua, Norway, arranged by Dept. of Orthopaedics, OUH and collaborating units.
CIRRO research coordinator Marte Traae Magnusson also attended a user meeting for TSD, UiO, to continue and optimize the work with electronic datacollection in clinical research. She also gave lectures at Tønsberg Hospital regarding GCP and evidence based practice.
Other highlights of this year were the completion of three PhD programs. We congratulate and are proud of Dr. med. Justin van Leeuwen for his PhD in March, titled “Evaluation of Patient-Spesific Positioning Guides in knee arthroplasty”; Dr. philos. Eirik Aunan for his PhD in April, titled “Improving surgical technique and functional outcome of TKA” and finally Dr. med. Gunnar Petursson for his PhD in August, titled “Computer navigation and fixation in total knee replacements”. All did a great defence with interntionally appreciated reviewers.
Justin van Leeuwen
Eirik Aunan
Gunnar Petursson
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Ongoing projects
Hip projects
∙ Randomized study between operation with pins with or without plate for undisplaced dislocated femoral neck fracture. Radio stereogrammetric analysis (RSA) of stability and fracture healing and clinical endpoints. (The Pinloc Study)
∙ RCT on the function of the Trochanteric Support Plate (TSP) in combination with the Dynamic Hip Screw (DHS)
∙ Solutions for patients at risk: dislocation, hip spine syndrome
∙ The value of minimal invasive approaches for THP compared to traditional ones Knee projects
∙ In vivo kinematics and performance of contemporary knee arthroplasty (PhD project OUH, in collaboration with HF Møre Romsdal)
∙ Kinematic RSA of three different kneedesignes (collaboration with Lovisenberg Hospital) Methodological projects
∙ Precision of RSA with different RSA systems
∙ Phantom study of the hip and the knee during motion
∙ Motionanalysis with CT Ankle and foot projects
∙ Investigating acute Lisfranc injuries in the foot and a new surgical procedure (PhD project OUH)
∙ Kinematics of the midfoot after Lisfranc injury (PhD project OUH) Shoulder project
∙ Stability of the glenoid implant in reversed shoulder arthroplasty (PhD project OUH) Hand project
∙ A prospective randomized trial comparing two different wrist arthroplasties (PhD project OUH) Spinal project
∙ INTRAKS study on spinal derformities (https://www.intraks.org)
Funding
‐ South-Eastern Norway Regional Health Authority (PhD program)
‐ Bergen University (PhD program)
‐ Oslo University (2 PhD program)
‐ Medacta International AG
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Most important national and international collaborators
National International
‐ Norwegian Arthroplasty register (NAR)
‐ Norwegian society for hip and knee surgery (NFHKK)
‐ Betanien Hospital Skien
‐ Diakonhjemmet Hospital
‐ Lillehammer Hospital
‐ Lovisenberg Diaconal Hospital
‐ Oslo Sports Trauma Research Center (OSTRC)
‐ Regional Health Autority Møre Romsdal
‐ Kristiansund hospital
‐ Haukeland University Hospital
‐ Arendal Hospital
‐ Umeå University Hospital, Arthroplasty unit, Sweden
‐ UmRSA Biomedical, Sweden
‐ Leiden University, The Netherlands
‐ Kyoto University Orthopedic Association, Japan
‐ Helsinki bone and joint research group, Finland
‐ Skåne University, Sweden
Scientific production of the research group in 2019
Peer reviewed original research articles: 23
Selected publications:
Brun OL, Sund HN, Nordsletten L, Röhrl SM, Mjaaland KE (2019)
“Component Placement in Direct Lateral vs Minimally Invasive Anterior Approach in Total Hip Arthroplasty: Radiographic Outcomes From a Prospective Randomized Controlled Trial”
J Arthroplasty, 34 (8), 1718-1722 DOI 10.1016/j.arth.2019.04.003 PubMed 31053468
Flatøy B, Dahl J, Röhrl SM, Nordsletten L (2019)
“Does radiopaque cement conceal periprosthetic bone loss around femoral stems?“
Hip Int, UNSP 1120700019863352 DOI 10.1177/1120700019863352 PubMed 31359800
Halvorsen V, Fenstad AM, Engesæter LB, Nordsletten L, Overgaard S, Pedersen AB, Kärrholm J, Mohaddes M, Eskelinen A, Mäkelä KT, Röhrl SM (2019)
“Outcome of 881 total hip arthroplasties in 747 patients 21 years or younger: data from the Nordic Arthroplasty Register Association (NARA) 1995-2016“
Acta Orthop, 90 (4), 331-337 DOI 10.1080/17453674.2019.1615263 PubMed 31088343
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Hand
Group Leader
Magne Røkkum, Dept. of Orthopaedics, UiO ([email protected]) /OUS ([email protected])
Research profile and aims
Clinical and experimental research related to hand, microsurgery and peripheral nerves.
Ongoing projects
∙ Bratberg H: Prospective randomized trial between Percutan Needle Fasciotomy and Clostridium Histolyticum injection for Dupuytrens Contracture
∙ Williksen JH et al.: Complications and secondary surgeries after volar plating of distal radius fractures
∙ Williksen JH et al: Radiological results and clinical outcomes after operative treatment of distal radius fractures
∙ Hassellund S: Pinning of unstable distal radius fractures gives acceptable long term clinical results
∙ Hassellund S: Treatment of distal radus fractures in patients over 65 years, a health economic analyses
∙ Hassellund S: Effect of reposition of wrist fractures in patients over 65 years
∙ Hassellund S: Corticosteroids in addition to plexus blockades
Group Members
∙ Hallgeir Brattberg, OUH
∙ Sondre Hassellund, Faculty of Medicine, UiO
∙ May Tove Hestmo, OUH
∙ Trygve Holm Glad,student, Faculty of Medicine, UiO
∙ Johanne Korslund, OUH
∙ Lars-Eldar Myrseth, OUH
∙ Trond Refsnaes, student, Faculty of Medicine, UiO
∙ Ole Reigstad, OUH
∙ Istvan Rigo
∙ Ida Neergård Sletten, OUH
∙ Rasmus Thorkildsen, student, Faculty of Medicine, UiO
∙ Frode Thu, student, Faculty of Medicine, UiO
∙ Tone Vaksvik, OUH
∙ Maria Vatne, OUH
∙ Kristin Wennesland Øren
∙ John H. Williksen, OUH
∙ Mona Winge, student, Faculty of Medicine, UiO
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∙ Korslund J: Outcomes after finger replantation
∙ Vatne M: Monitoring of the vascularisation in replantated fingers
∙ Vatne M: Hand function in Hurler’s disease
∙ Hestmo MT: Replantation in children
∙ Vaksvik T: Continued decrease in cold hypersensitivity after surgery for complex hand injuries: A prospective cohort study over eight years
∙ Refsnaes T: Dysmelia of the upper extremity
∙ Thorkildsen R: Proximal injuries of the ulnar nerve
∙ Thorkildsen R: Nerve complicetions after elbow fractures in children
∙ Thorkildsen R: Follow-up of 50 ARPE trapeziometacarpal arthroplasties
∙ Størseth M, Eriksen BK, Kindgren LMC, Vaksvik T: Assessment of activity challenges in patients with hand injuries using Measure of Activity Performance of the Hand (MAP-hand)
∙ Vaksvik T and Stavenes AB: Norwegian contribution to International validation of Children´s Hand Use Questionnaire (CHEQ)
∙ Eriksen BK and Vaksvik T: Activity problems related to cold hypersensitivity in patients with hand injuries
∙ Vaksvik T, Røkkum M, Holm I: Use of strategies to limit cold-related symptoms 7 years after hand injury
∙ Reigstad O: Follow-up of wrist prostheses
∙ Reigstad O: Intercarpal Arthrodes
∙ Reigstad O: Darrach’s procedure versus arthroplasty for radioulnar osteoarthritis (The Nordurr study)
PhD:
∙ Sondre Hassellund: Unstable distal radius fractures in patients over 65 years. Conservative treatment vs operative treatment with volar locking plate. RCT
∙ Rasmus Thorkildsen: Total joint replacement or interpositional arthroplasty for the treatment of carpometacarpal thumb arthritis
∙ Mona Winge: Is calcium phosphate bone cement an alternative to bone graft?
∙ Trygve Holm Glad: Randomized controlled trial between two total wrist arthroplasties. A clinical, radiostereometric and DEXA study
∙ Frode Thu: Injuries of the plexus brachialis
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Most important national and international collaborators
National International
- Prof. Jan Erik Madsen, MD, PhD
- Dept. of Otorhinolaryngology, Head and Neck Surgery, OUH
- Prof. Carina B Johansson, Dept. of Biomaterials, University of Gothenburg, Sweden
Scientific production of the research group in 2019
Peer reviewed original research articles: 2
Thorkildsen RD, Røkkum M.
“Trapeziectomy with LRTI or joint replacement for CMC1 arthritis, a randomised controlled trial”
J Plast Surg Hand Surg. 2019 Dec;53(6):361-369. doi: 10.1080/2000656X.2019.1635490. Epub 2019 Jul 4.
PMID: 31271330
Reigstad O, Holm-Glad T, Korslund J, Grimsgaard C, Thorkildsen R, Røkkum M.
“High re-operation and complication rates 11 years after arthrodesis of the wrist for non-inflammatory arthritis”
Bone Joint J. 2019 Jul;101-B(7):852-859. doi: 10.1302/0301-620X.101B7.BJJ-2018-0943.R4. PMID:
31256671
Funding
- Sophies Minde Ortopedi AS
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Norwegian research center for Active Rehabilitation – NAR
Group Leader
May Arna Risberg, Professor, The Norwegian School of Sport Sciences
([email protected]) / Division of Orthopaedic Surgery, OUH ([email protected])
Research profile and aims
The vision of the group is to be an internationally leading research center within the field of active rehabilitation of musculoskeletal injuries and disorders.
Main Goals
Active rehabilitation of patients with musculoskeletal injuries and disorders
∙ Clinical research
∙ Implementation of the research to evidence based practice
Our current research areas include active rehabilitation of knee and hip injuries and knee and hip osteoarthritis (OA). Each research area consists of a research team with senior researchers, PhD fellows, clinicians and a research coordinator.
Group Members and affiliated members
∙ Hege Grindem, PT, PhD, Nimi/The Norwegian School of Sport Sciences
∙ Nina Kise, MD, Faculty of Medicine, University of Oslo (UiO), and Martina Hansens Hospital
∙ Britt Elin Øiestad, PT, PhD, OsloMET
∙ Marie Pedersen, PT, MSc, PhD student
∙ Bjørnar Berg, PT, PhD student
∙ Kristian Marstrand Warholm, MD, PhD student
∙ Kristin Bølstad, MSc, Nimi
∙ Marte Lund, PT, MSc, Nimi
∙ Odd-Einar Svinøy, PT, PhD student
∙ Guri R. Ekås, MD, PhD student
∙ Lars Nordsletten, MD, PhD, professor, OUH and Faculty of Medicine, UiO
∙ Lars Engebretsen, MD, PhD, professor, OUH and Faculty of Medicine, UiO
∙ Inger Holm, PT, PhD, professor, OUH and Faculty of Medicine, UiO
∙ Lynn Snyder-Mackler, PT, PhD, professor, University of Delaware, USA
∙ Joanne Kemp, PT, PhD, LaTrobe University, Melbourne, Australia
∙ Ewa Roos, PT, PhD professor, University of Southern Denmark, Odense, Denmark
∙ Nina Østerås, PT, PhD, NKRR, Diakonhjemmet Hospital
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Ongoing projects
Knee
∙ Dynamic stability of the ACL-deficient knee (Delaware Oslo ACL Cohort). A research collaboration with the University of Delaware, USA
∙ The OMEX Study: The effect of arthroscopic partial meniscectomy or exercise therapy as treatment of degenerative meniscus tears in middle-aged patients. A Randomized controlled trial
∙ Efficacy of strength training and cycling on physical function and cartilage health in patients with knee osteoarthritis – A randomized controlled trial
∙ Prospective cohort study of ACL injured children under the age of 13 years
∙ Is good muscle function a protective factor for early features of knee osteoarthritis after ACL reconstruction? A prospective cohort study. Shield Study
Hip
∙ HIPARTI (Hip Arthroscopy International) and HARP (Hip Arthroscopy Prospective)
∙ Better before – better after: Efficasy of prehabilitation for older patients with osteoarthritis awating total hip replacement – A randomized controlled trial
Osteoarthritis
∙ Active A - Active living with osteoarthritis (www.aktivmedartrose.no)
Most important national and international collaborators
National
‐ Martina Hansens Hospital
‐ Akershus University Hospital
‐ Diakonhjemmet Hospital
‐ Norwegian School of Sport Sciences
‐ Nimi
International
‐ University of Delaware, US
‐ University of Southern Denmark (SDU), Denmark
‐ LaTrobe University, Melbourne, Australia
Scientific production of the research group in 2019
(not included affiliated members) Peer reviewed original research articles: 1724 Invited lectures at international congresses: 13
Grindem H. Early complications after ACL injury or surgery. Swedish knee days, Gothenburg, Sweden, October 18- 19th, 2019
Grindem H. Rehabilitation progressions after ACL injury or surgery. Swedish knee days, Gothenburg, Sweden, October 18- 19, 2019
Grindem H. Sport-specific rehabilitation after ACL injury or surgery. Swedish knee days, Gothenburg, Sweden, October 18- 19, 2019
Grindem H. Decision-making in managing ACL injuries from diagnosis to return to sport. 3rd GISPT international conference, Verona, Italy, June 8-9th, 2019
Grindem H. Return to sport and how to avoid return to treatment. Scandinavian Congress of Medicine and Science in Sports, Copenhagen, Denmark, January 31st- February 2nd, 2019
Risberg MA. Femoroacetabular impingement (FAI)- evidens for behandling og presentasjon av prosjekter. Forskning og kliniker seminar, Gothenburg, Sweden, March, 2019
Risberg MA. The role of exercise in hip OA. Exercise works: putting science into action, Luxembourg, May 15th,2019
Risberg MA. Standardized Outcomes I: What has been used vs What do we want to know Functional outcomes. Optimizing Musculoskeletal Health after Knee Injury (OPTIKNEE), Advancing an International Research Agenda to Standardize Outcomes, Promote Collaborations and Reduce the Burden of
Osteoarthritis. 2019 OARSI World Congress on Osteoarthritis, Toronto, Canada, May 2-5th, 2019 Risberg MA. Physical treatment targets/strategies for prevention of post-traumatic osteoarthritis after ACL injury (Secondary prevention). Pre-congress workshop: Approaches to Preventing Post-Traumatic OA In Sport And The Military. 2019 OARSI World Congress on Osteoarthritis, Toronto, Canada, May 2-5th, 2019
Risberg MA. Physiotherapist- led treatment for young to middle-aged active adults with hip-related pain: Consensus recommendations from the International Hip-related Pain Research Network, Zurich 2018 (FAI). ASICS Sports Medicine Australia Conference, Twin Waters, Australia, October 23rd to 26th, 2019
Risberg MA. Exercise management of hip OA (Hip OA: Symposium on Non-surgical management of Osteoarthritis). ASICS Sports Medicine Australia Conference, Twin Waters, Australia, October 23rd to 26th, 2019
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Risberg MA. Best-practice approach to rehabilitation after ACL injury - Secrets to achieving outstanding outcomes after ACL rehabilitation (Knee symposium). ASICS Sports Medicine Australia Conference, Twin Waters, Australia, October 23rd to 26th, 2019
Warholm KM. HIPARTI RCT of hip arthroscopy vs. sham surgery. ISHA 2019 Annual Scientific Meeting, Madrid, Spain, October 17-19th, 2019
Selected publications:
Kise NJ, Aga C, Engebretsen L, Roos EM, Tariq R, Risberg MA.
“Complex Tears, Extrusion, and Larger Excision Are Prognostic Factors for Worse Outcomes 1 and 2 Years After Arthroscopic Partial Meniscectomy for Degenerative Meniscal Tears: A Secondary Explorative Study of the Surgically Treated Group From the Odense-Oslo Meniscectomy Versus Exercise (OMEX) Trial”
Am J Sports Med. 2019 Aug;47(10):2402-2411. doi: 10.1177/0363546519858602. Epub 2019 Jul 12.
PMID: 31298923
Lie MM, Risberg MA, Storheim K, Engebretsen L, Øiestad BE.
“What's the rate of knee osteoarthritis 10 years after anterior cruciate ligament injury? An updated systematic review”
Br J Sports Med. 2019 Sep;53(18):1162-1167. doi: 10.1136/bjsports-2018-099751. Epub 2019 Apr 1. PMID: 30936063
Ekås GR, Laane MM, Larmo A, Moksnes H, Grindem H, Risberg MA, Engebretsen L.
“Knee Pathology in Young Adults After Pediatric Anterior Cruciate Ligament Injury: A Prospective Case Series of 47 Patients With a Mean 9.5-Year Follow-up”
Am J Sports Med. 2019 Jun;47(7):1557-1566. doi: 10.1177/0363546519837935. Epub 2019 Apr 29.
PMID: 31034243
Funding
‐ South-Eastern Norway Regional Health Authority
‐ National Institutes of Health (NIH) # R37HD037985E
‐ Sophies Minde
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Oncological Orthopedics
Group Leader
Olga Zaikova, Dept. of Orthopaedics, OUH ([email protected])
Research profile and aims
The treatment of sarcoma is multidisciplinary, and this is reflected in the need of extensive cooperation between several research groups. The aim is to participate in the multidisciplinary research on sarcoma.
The strategy is to build up research networks, both nationally and internationally, and to participate in a wide spectrum of research projects from basic research and translational research to clinical studies and retrospective quality studies.
Ongoing projects
∙ A study of epidemiology and outcome in chondrosarcoma, PhD project (Joachim Thorkildsen)
∙ A nation wide study of Ewing sarcoma, PhD project (Thale Marie Asp Strøm)
∙ SACRO Sacral Chordoma: a Randomnized & Oberservational study on surgery versus definite radiation therapy in primary localized disease. A multinational clinical trial
∙ DOREMY DOse REduction of preoperative radiotherapy in MYxoid liposarcomas. A multinational clinical trial
∙ A study of muscle strength, balance and gait function in patients with tumor in the knee joint - a pilot study (MAGUS)
∙ Nordic Megaprosthesis Register (Merethe Lia Johansen, OUH)
Most important national and international collaborators
National International
- Norwegian National Advisory Unit for Sarcomas
- Department of Oncology, OUH - Department of Tumor Biology,
Institute for Cancer Research, OUH
- Scandinavian Sarcoma Group (SSG)
- European Muscolo-Skeletal Oncology Society (E.M.S.O.S)
- European Reference Network ERN EURACAN
Group Members
Ole-Jacob Norum, MD, PhD, OUH Simen Sellevold, MD, OUH Joachim Thorkildsen, MD, OUH Thale Marie Asp Strøm, MD, OUH Trygve Wessel-Aas, MD, OUH
27
Scientific production of the research group in 2019
Peer reviewed original research articles: 2
Thorkildsen J, Taksdal I, Bjerkehagen B, Haugland HK, Børge Johannesen T, Viset T, Norum OJ, Bruland Ø, Zaikova O.
“Chondrosarcoma in Norway 1990-2013; an epidemiological and prognostic observational study of a complete national cohort”
Acta Oncol. 2019 Jan 11:1-10. doi: 10.1080/0284186X.2018.1554260. [Epub ahead of print]
PubMed PMID: 30632866.
Papworth KE, Arroyo VM, Styring E, Zaikova O, Melin BS, Lupo PJ.
“Soft-tissue sarcoma in adolescents and young adults compared with older adults: A report among 5000 patients from the Scandinavian Sarcoma Group Central Register”
Cancer. 2019 Oct 15;125(20):3595-3602. doi: 10.1002/cncr.32367. Epub 2019 Jul 9.
PubMed PMID: 31287163.
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Orthopaedic traumatology
Group Leader
Jan Erik Madsen, Professor, Dept. of Orthopaedics ([email protected])/
Consultant, Orthopaedic Trauma, OUH ([email protected])
Research profile and aims
The Orthopaedic Trauma Research Group aims to initiate and conduct clinical and experimental trials at a high international level related to Orthopaedic Trauma. 15–25 continuously ongoing PhD projects, mainly externally financed, provide the main scientific production. Local and national registries on pelvic fractures, hip fractures and polytrauma are major contributors to high quality clinical studies.
Ongoing projects
∙ “Does the trochanteric stabilizing plate increase stability in trochanteric hip fractures?” Carl Erik Alm
∙ “Biomechanical studies of the effect of different fixations upon stability of hip fractures”. Jan Egil Brattgjerd
∙ “Reversed arthroplasty in the treatment of proximal humerus fractures. Randomized controlled trial and evaluation of glenoid component migration by RSA”. Alexander Fraser
∙ External validity and health economics in the treatment of proximal humeral fractures in the elderly”. Jonas Bjordal
∙ “Surgical treatment of the distal radius fracture”. Ola-Lars Hammer
Group Members
∙ Geir Andreassen, Consultant
∙ Tone Bere, Research Coordinator, PhD
∙ John Clarke- Jenssen, Consultant PhD
∙ Sigbjørn Dimmen, Consultant, PhD
∙ Wender Figved, Consultant, PhD
∙ Tore Fjalestad, Consultant, PhD
∙ Gunnar Flugsrud, Consultant, PhD
∙ Frede Frihagen, Consultant, PhD
∙ Johan Hellund, Consultant, PhD
∙ Elisabeth Ellingsen Husebye, Consultant, PhD
∙ Kjetil Hvaal, Consultant, PhD
∙ Lene Solberg, Consultant, PhD
∙ Arnlaug Wangensteen, Research Coordinator, PhD
∙ Jan Erik Madsen, Professor UiO / Consultant OUH
∙ Lars Nordsletten, Professor UiO / Consultant OUH
∙ Olav Røise, Professor UiO / Consultant OUH
∙ Harald Steen, Professor OsloMet/ Consultant OUH
29
∙ “Conservative versus operative treatment of distal radius fractures”. Sondre Hassellund
∙ “Effects of bone resorption inhibition and bone formation stimulation on bone and tendon- to- bone healing: Experimental studies in the rat”. Geir Hjorthaug
∙ “Primary and secondary total hip arthroplasty following acetabular fractures”. Ragnhild Kirkebø
∙ “Fracture- dislocations of the elbow”. Kaare Midtgaard
∙ “Treatment of the unstable syndesmosis in ankle fractures”. Lise Benedicte Wendt Ræder
∙ “Gastrocnemius recession in foot disorder”. Marius Molund
∙ “Treatment of Charcot neuropathy of the foot”. Fredrik Nilsen
∙ “Complex fractures around the elbow”. Anne- Mari Rosenlund
∙ “Biomechanics of the unstable ankle fracture”. Ingrid Kvello Stake
∙ “Acute injuries to the Lisfranc joint complex”. Are Stødle
∙ “Road traffic injuries at a large referral hospital in Malawi: elucidating strategies for prevention”.
Mads Sundet
∙ “Function and complications in hip fractures”. Stian Svenøy
∙ “In vitro development of a ligament and in vivo analysis of the bone-soft tissue interface”. Endre Søreide
∙ “Surgical treatment and complications in fractures of the distal radius”. John Williksen
Most important national and international collaborators
National International
- Akerhus University Hospital (AHUS) - Asker & Bærum Hospital
- Institute for Surgical Research, OUH - Lovisenberg Diaconal Hospital - Norwegian School of Sport Sciences - Sunnaas Rehabilitation Hospital - The Norwegian Arthrosplasty Register - Østfold Hospital Health Authority
- University of Tampere, Finland - Aarhus University Hospital, Denmark - AO Trauma / Orthopaedic Trauma
Association classification committee - New Royal Adelaide Hospital, Australia - Sahlgrenska University Hospital,
Gothenburg, Sweden
- Steadman Philippon Research Institute, Colorado, USA
- Uppsala University Hospital, Sweden
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Scientific production of the research group in 2019
PhD dissertation:
Kjersti Kaul Jenssen:
“Arthroscopic rotator cuff repair in the shoulder. Clinical outcomes and radiological results: Prognostic factors, postoperative rehabilitation and treatment of acute postoperative infection”.
Lovisenberg Hospital, Jan 18, 2019
Peer reviewed original research articles: 28
Invited lectures at international congresses: Numerous
Selected publications:
HEALTH Investigators, Bhandari M, Einhorn TA, Guyatt G, Schemitsch EH, Zura RD, Sprague S, Frihagen F, Guerra-Farfán E, Kleinlugtenbelt YV, Poolman RW, Rangan A, Bzovsky S, Heels-Ansdell D, Thabane L, Walter SD, Devereaux PJ (2019)
“Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture”
N Engl J Med, 381 (23), 2199-2208
DOI 10.1056/NEJMoa1906190, PubMed 31557429, WoS 000505219800005 (Details)
Soreide E, Denbeigh JM, Lewallen EA, Thaler R, Xu W, Berglund L, Yao JJ, Martinez A, Nordsletten L, van Wijnen AJ, Kakar S (2019)
“In vivo assessment of high-molecular-weight polyethylene core suture tape for intra-articular ligament reconstruction: an animal study”
Bone Joint J, 101-B (10), 1238-1247 DOI 10.1302/0301-620X.101B10.BJJ-2018
1282.R2, PubMed 31564153, WoS 000488617100010 Cristin 1766139 (Details)
Borgen TT, Bjørnerem Å, Solberg LB, Andreasen C, Brunborg C, Stenbro MB, Hübschle LM, Froholdt A, Figved W, Apalset EM, Gjertsen JE, Basso T, Lund I, Hansen AK, Stutzer JM, Omsland TK, Nordsletten L, Frihagen F, Eriksen EF (2019)
“Post-fracture Risk Assessment: Target the Centrally Sited Fractures First! A Substudy of NoFRACT”
J Bone Miner Res, 34 (11), 2036-2044
DOI 10.1002/jbmr.3827, PubMed 31310352, WoS 000481461100001 Cristin 1734523 (Details)
Funding
‐ South-Eastern Norway Regional Health Authority
‐ UiO
‐ OUH
‐ Endowment and funds
31
Oslo Sports Trauma Research Center - OSTRC
Group Leaders
Lars Engebretsen, Professor, UiO ([email protected]), MD/PhD
Roald Bahr (Co-chair) Professor, NIH ([email protected]), MD/PhD
Group Members
∙ Ingar Holme, Professor, OSTRC/NIH
∙ Grethe Myklebust, PhD/PT, Professor, OSTRC/NIH
∙ Tron Krosshaug, MSc/PhD, A/Professor, OSTRC/NIH
∙ Thor Einar Andersen, MD/PhD, Professor, OSTRC
∙ Morten Wang Fagerland, PhD, Associate Professor
∙ Kathrin Steffen, MSc/PhD, Research Scientist, OSTRC
∙ Asbjørn Årøen, MD/PhD, Professor, Ahus
∙ Håvard Moksnes, PT/PhD, Research Scientist, OSTRC/Olympiatoppen
∙ Agnethe Nilstad, PT/PhD, Research Scientist, OSTRC/OUS
∙ Ben Clarsen, PT/PhD, Research Scientist, OSTRC/Olympiatoppen
∙ Sverre Løken, MD/PhD, OUH
∙ Robert LaPrade, MD/PhD, Steadman Institute, Vail Colorado
∙ Truls Straume-Næsheim, MD/PhD, Ahus
∙ Rune B Jakobsen, MD/PhD, OUS/Ahus
∙ Hilde Moseby Berge, MD/PhD, Olympiatoppen
∙ John Bjørneboe, MD/PhD, OSTRC
∙ Cathrine N Engen, MD/PhD fellow, Ahus/OSTRC
∙ Cathrine Aga, MD/PhD fellow, Martina Hansens Hospital
∙ Christine Holm Moseid, MD/PhD fellow, OSTRC
∙ Gilbert Moatshe, MD/PhD fellow, OUH
∙ Guri R Ekås, MD/PhD fellow, OSTRC/OUH
∙ Christian Owesen MD/PhD fellow, Ahus
∙ Svend Ulstein MD/PhD fellow, Ahus
∙ Sophie Steenstrup PhD fellow/PT, OSTRC
∙ Arnlaug Wangensteen, PhD fellow/PT, Aspetar
∙ Joar Harøy, PhD fellow/PT, OSTRC
∙ Marc Jacob Strauss, MD, OUH
∙ Christopher Skazalski, PhD fellow/PT, Aspetar
∙ Katherine Wang, Stud.med., UiO
∙ Stian Kjennevold, MD/Phd fellow, Ahus
∙ Cecilie B Isnern, MD/PhD fellow, OUH, Ahus
∙ Torstein Dalen-Lorentsen, PhD fellow, OSTRC
∙ Hilde Fredriksen, PT/PhD fellow, OSTRC
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Research profile and aims
The Oslo Sports Trauma Research Center is established at the Norwegian School of Sport Sciences as a joint research venture between the Department of Orthopaedic Surgery (Oslo University Hospital), and the Department of Sports Medicine (Norwegian School of Sport Sciences). The aim is to prevent injuries and other health problems in sports through research on risk factors, injury mechanisms, and prevention methods, with a particular emphasis on football, team handball, and alpine skiing/snowboarding. In addition to primary injury prevention research, our cartilage and ligament research group is focused on secondary prevention, i.e. surgical and nonsurgical treatment options to prevent future osteoarthritis.
The goal of the center is to strengthen Norwegian health research by providing a catalyst for innovation among highly-ranked researchers and delivering superior research training and mentorship. The emphasis is not only on the production of new knowledge, but also the translation of research findings into improvements in the health of Norwegians and the Norwegian health care system.
Ongoing projects
In 2019 the Oslo Sports Trauma Research Center has published 62 articles in international journals with peer review. Fourteen master’s students have defended their master’s degrees and three PhD students have defended their dissertation. By the end of 2019 the Center had 90 ongoing projects, 3 accepted and 25 submitted articles. In addition, 29 projects were in the planning stage and 6 projects were temporarily on hold. You can find a complete list of projects in the Center’s annual rapport for 2019.
Group Members (continued)
∙ Nils F Holm Moseid, MD/PhD fellow, OSTRC
∙ Stian Sandmo, MD/PhD fellow, OSTRC
∙ Eirik Halvorsen Wik, PT/PhD fellow, Aspetar
∙ Monica Sailer, MD/PhD fellow, Ahus
∙ Anine Nordstrøm, MD/PhD fellow, Sykehuset Innlandet HF
∙ Dustin Nabhan, PhD fellow, OSTRC
∙ Nicholas DePhillipo, PhD fellow, OSTRC
∙ Roar Amundsen, PhD Fellow, OSTRC
∙ Solveig Thorarinsdottir, PT/PhD fellow, OSTRC
∙ Lena Bache-Mathiesen, Phd Fellow, OSTRC
∙ Hege Grindem, PT/PhD, Research Scientist, OSTRC
∙ Merete Møller, PT/PhD, Research Scientist, OSTRC
∙ Andreas Persson, MD/PhD, Research Scientist, OSTRC/OUH
Associated group members
∙ Inge Andersen, Database developer, MSc, OSTRC
∙ Tone Øritsland, MSc/Research coordinator, OSTRC
∙ Kaja Funnemark, PT/MSc, OSTRC
∙ Hege Heiestad, PT/MSc, OSTRC
∙ Emilie Bratt Jakhelln, MSc, OSTRC
∙ Erling Hisdal, MSc, OSTRC
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Most important national and international collaborators
National International
‐ The Norwegian Olympic and paralympic committee and confederation of sports
‐ Steadman Philippon Research Institute, Vail, US
‐ International Olympic Committee (IOC)
‐International Ski Federation
‐Federation Internationale de Football Association
‐Federation Internationale de Volleyball
Scientific production of the research group in 2019
Peer reviewed original research articles: 62 Other publications: 12
Invited lectures at international congresses: 32
Doctoral thesis:
Aga, Cathrine.
The effect of an anatomic double-bundle surgical technique on the outcome of anterior cruciate ligament reconstructions. Medisinsk fakultet, Universitetet i Oslo 2019. ISBN: 978-82-8377-359-0 Persson, Andreas.
Risk factors for revision after anterior cruciate ligament reconstruction. Universitetet i Bergen 2019.
ISBN: 9788230866771 Ulstein, Svend.
Prognosis and treatment of focal cartilage lesions of the knee joint: medium- to long-term results.
Medisinsk fakultet, Universitetet i Oslo 2019. ISBN: 9788283774474
Selected publications:
Ekås, Guri Ranum; Mjelde, Marit; Larmo, Arne; Moksnes, Håvard; Grindem, Hege; Risberg, May Arna;
Engebretsen, Lars.
“Knee pathology in young adults after pediatric anterior cruciate ligament injury - a prospective case series of 47 patients with a mean 9.5-year follow-up”
American Journal of Sports Medicine 2019; 47(7), 1557-1566
Moseid, Christine Holm; Myklebust, Grethe; Slåstuen, Marit Kyte; Bar-Yaacov, Jonathan Brun;
Kristiansen, Åse; Fagerland, Morten; Bahr, Roald.
“The association between physical fitness level and number and severity of injury and illness in youth elite athletes”
Scandinavian Journal of Medicine & Science in Sports. E-pub 2019
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Scott, Alex; LaPrade, Robert F.; Harmon, Kimberly G.; Filardo, Giuseppe; Kon, Elizaveta; Villa, Stefano Della; Bahr, Roald; Moksnes, Håvard; Torgalsen, Thomas; Lee, Jenny; Dragoo, Jason L.; Engebretsen, Lars.
“Platelet-rich plasma for patellar tendinopathy - a randomized controlled trial of leukocyte-rich PRP or leukocyte-poor prp versus saline”
American Journal of Sports Medicine 2019; 47(7), 1654-1661
Funding
‐ Norwegian Ministry of Culture
‐ The Research Council of Norway
‐ International Olympic Committee
‐ Norwegian Olympic and Paralympic Committee and Confederation of Sports
‐ International Ski Federation
‐ Norwegian School of Sport Sciences
‐ European Society for Sports Traumatology, Knee Surgery and Arthroscopy
‐ The Savings Bank Foundation DNB
‐ Various grants from other sources
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Research group SPINE
Group Leader
Christian Hellum, MD/PhD, Dept of Orthopaedics ([email protected])
Research profile and aims
The main intention of the group is to promote clinical spine research.
Group Members
∙ Thomas Kibsgård, MD/PhD
∙ Jon Dahl, MD/PhD
∙ Kjetil Kivle,MD, PhD-cand
∙ Ellen Aksnes,MD
∙ Roger Trana,MD
∙ Ole Rasmus Robak, MD
∙ Mads Peder Rolfsen, MD,PhD-cand
∙ Torstein Schrøder-Aasen, MD/PhD
∙ Engelke Randers, MD, PhD-cand
∙ Filip Dolatowski, MD, PhD
Associate Group Members
∙ Kjersti Storheim, Professor
∙ Jens Ivar Brox, Professor
∙ Kari Indrekvam, Professor
∙ Oliver Grundnes,MD/PhD
∙ Tore Solberg, MD/PhD
∙ Britt Stuge, Physical therapist, PhD
∙ Inger Holm, Professor
∙ Ragnhild Molland, PhD-cand
∙ Ivar Austevoll, MD, PhD-cand
∙ Håvard Furunes, MD, PhD-cand
∙ Erland Hermansen, MD, PhD-cand
∙ Frode Rekeland, MD, PhD-cand
∙ Stehpan Røhrl MD/PhD
∙ Vinjar Myklevold MD
∙ Anvar Masoud MD/PhD
∙ Hasan Banitalebi MD
∙ Karianne Gammelsrud MD/PhD
∙ Sverre Mjønes MD
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Ongoing projects
National multicentre studies and PhD:
∙ NORDSTEN-study – clinical trials comparing the efficacy of different surgical methods for spinal stenosis and degenerative spondylolisthesis and spinal stenosis. Most hospitals in Norway performing spine surgery participate, including orthopaedic and neurosurgical departments. Christian Hellum is the leader of the scientific committee. He is also the main superviser for Ivar Austevoll and co- superviser for Frode Rekeland and co-supervised Erland Hermansen, who had his dissertation in 2019.
∙ Modic study – started in May 2015 (financed by NFR, The Western Norway Regional Health Authority and Central Norway Regional Health Authority, and including 3 doctoral students ). This is a double- blind clinical trial evaluating the effectiveness of antibiotics in selected patients with back pain and altered endplate morphology. Main outcomespublished in 2019. Futhermore a biopsi study on patients with Modic changes was planned in 2016, and started in 2018. Mads Peder Rolfsen is a PhD candidate in this project, supervised by Christian Hellum. AHUS and Haukeland University Hospital participate in the biopsy study. Furhter Bærum Hospital and the University Hospital of Stavenger will include patents in 2020. This collaboration also include the department of Microbiology by Karianne Gammelsrud, Pathology and Medical Genetics at Oslo University Hospital.
∙ SIFSO study – (SacroIlilac Fusion vs Sham Operation) Started the inclution of patients in august 2018.
This is a double blinded randomized controlled trial comparing sacroiliac joint fusion vs sham surgery.
Engelke Randers is the PhD candidate and the project is supervized by Thomas Kibsgård and John Dahl.
This is a collboration with prof. Gerdhem in Karolinska Hospital in Stockholm, Sweden.
∙ Improving the diagnostic accuracy, reproducibility and clinical usefulness og MRI and X-ray in patients with lumbar spinal stenosis (Data from the NORDSTEN-study)
PhD student Hasan Banitalebi
Supervisor: Anne Negård, Christian Hellum, Anvar Masoud Status: Protocol in planning
Other studies and PhD:
∙ “Long-term follow-up disc prosthesis and multi-diciplinary rehabilitation”
(grants from South-Eastern Norway Regional Health Authority, doctoral student at OUH) PhD-student Håvard Furunes
Supervisors: Kjersti Storheim, Christian Hellum, Jens Ivar Brox Status: Three articles submitted, PhD 2019
∙ “Physical activity, motor function, lung function and quality of life in children with early onset scoliosis treated with non-fusion spine correction”
PhD student: Ragnhild Molland, physical therapist
Supervisors: Thomas Kibsgård, Jens Ivar Brox, Britt Stuge, Inger Holm
Status: One article publishedand data collection finished. Second paper written but not submitted.
∙ “Sacroiliac joint fusion for treatment of sacroiliac pain”
PhD student: Engelke Randers, resident
Supervisors: Thomas Kibsgård, John Dahl, Britt Stuge Status: Study started
