Inflammation and atherosclerosis

Inflammation and atherosclerosis

Risk associations in the HUNT surveys

Thesis for the degree of Philosophiae Doctor Trondheim, June 2012

Norwegian University of Science and Technology Faculty of Medicine

Department of Laboratory Medicine, Children’s and Women’s Health

Inga Thorsen Vengen

NTNU

Norwegian University of Science and Technology Thesis for the degree of Philosophiae Doctor Faculty of Medicine

Department of Laboratory Medicine, Children’s and Women’s Health

© Inga Thorsen Vengen

ISBN 978-82-471-3597-6 (printed ver.) ISBN 978-82-471-3598-3 (electronic ver.) ISSN 1503-8181

Doctoral theses at NTNU, 2012:155

Printed by NTNU-trykk

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Cardiovascular diseases

• Ischemic heart disease

• Cerebrovascular disease

• Diseases of the aorta and arteries (including hypertension and peripheral vascular disease)

• Rheumatic heart disease

• Congenital heart disease

• Cardiomyopathies

• Cardiac arrhythmias

Table 1.1 Definition of cardiovascular diseases

Worldwide distribution of major causes of death

Injuries 9%

Communicable diseases* 27%

All-cause CVD 31%

Other non-communicable diseases 33%

Figure 1.1 All-cause CVD is the leading cause of death worldwide. *Communicable, maternal, perinatal and nutritional conditions. Modified from WHO.

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Worldwide distribution of cardiovascular deaths

Ischemic heart disease 42%

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Figure 1.2Deaths due to myocardial infarction, stroke and other types of cardiovascular

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Behavioral risk factors

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Lifestyle related disease

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•Hypertension

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Figure 1.3 Risk factors for atherosclerotic CVD.

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Right coronary artery

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Figure 1.5 Myocardial infarction due to plaque rupture.

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