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Instituttenes vurdering av den internasjonale konkurransen

As misturas PF30, PF50 E PF70 mostram-se alternativas promissoras para o uso em formulações ou veículos de fármacos hidrofóbicos, sendo compatíveis com as características de geleificação do constituinte F127 puro conforme os dados obtidos por diagrama de fase e reologia.

Para o fármaco griseofulvina observou-se que as estruturas micelares imersas em aditivo PEG 35K a uma concentração de 1% apresentou melhores valores de solubilização quando comparado às outras concentrações de aditivo e que, a mistura binária PF70 apresentou um valor superior comparado às outras porções. Isso se deve ao fato de que com o aumento da estrutura hidrofóbica, ou seja, aumento da porção de P123 na micela acarretará um aumento na solubilização do fármaco, já que o mesmo também apresenta uma hidrofobicidade acentuada.

A solubilidade do bioativo oncocalixona A apresentou-se alta em meio aquoso (33,30 mg/dl) em relação ao fármaco griseofulvina (1,83 mg/dl), apresentando uma hidrofilicidade mais proeminente. O aumento da constituição hidrofóbica (P123) na construção micelar causou, nas proporções de um modo geral, um aumento na solubilização da droga na presença do surfactante em relação às micelas imersas apenas em água (o aumento da parte hidrofóbica acarreta numa melhor estabilização micelar). Contudo, o surfactante forneceu às misturas uma estabilidade maior quando apenas em meio aquoso. Podemos justificar esse fato às características relacionadas anteriormente, como por exemplo, ser biocompatível e apresentar uma alta afinidade ao copolímero F127.

De acordo com os dados obtidos ao tamanho micelar das misturas e do copolímero P123 em PEG35K, na ausência e na presença da droga oncocalixona A, observou-se que os mesmos apresentaram picos abaixo de 200 nm, sugerindo assim, que houve a comicelização das misturas, sendo uma atraente ferramenta na entrega de fármacos.

O bioativo oncocalixona A por apresentar várias propriedades farmacológicas, dentre elas a atividade antitumoral, e por ser pioneira no estudo relacionado à construção de micelas que visam a entrega de fármacos, torna-se uma possível ferramenta para o tratamento de cânceres.

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