Os resultados obtidos neste trabalho permitem as seguintes conclusões:
Candida albicans foi a espécie mais prevalente entre os isolados de Candida spp. oriundos da cavidade oral de pacientes transplantados renais analisados neste trabalho.
Todos os isolados de Candida pertencentes a este estudo apresentaram-se viáveis após a reativação, bem como características sugestivas de cada espécie re-identificada.
Cepas identificadas presuntivamente como Candida dubliniensis foram confirmadas como pertencentes a esta espécie através da genotipagem ABC.
Cepas identificadas como pertencentes ao complexo Candida parapsilosis foram diferenciadas através da genotipagem por RAPD, identidicando-se cepas das três espécies
que compõem o complexo Candida parapsilosis.
A viabilidade dos isolados de Candida spp. verificada após inativação pelo calor reforça a hipótese de que a ação do extrato de Eugenia uniflora diretamente sobre fatores de
virulência analisados.
Os isolados de Candida albicans tiveram uma maior capacidade de aderência às CEBHs do que os isolados de Candida não-Candida albicans.
Todos os isolados de Candida spp. analisados foram capazes de formar biofilme em superfície de poliestireno.
Os isolados de Candida tropicalis apresentaram uma maior capacidade de formar biofilme quando comparado às demais espécies de Candida, com destaque para duas
cepas altamente produtoras de biofilme;
O extrato de Eugenia uniflora interferiu na capacidade de adesão dos isolados de Candida spp., reduzindo a expressão in vitro deste fator de virulência.
A capacidade de formar biofilme foi reduzida para algumas cepas quando na presença do extrato de Eugenia uniflora, dentre elas as duas cepas de Candida tropicalis altamente
produtoras de biofilme.
O referido extrato vegetal poderá ser utilizado como modelo alternativo futuro em quadros de candidíase oral.
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